Literature summary for 3.4.17.24 extracted from

O'Hagan, R.; Piasecki, B.P.; Silva, M.; Phirke, P.; Nguyen, K.C.; Hall, D.H.; Swoboda, P.; Barr, M.M.
The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans (2011), Curr. Biol., 21, 1685-1694 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Mus musculus	5829	-
cytosol	-	Caenorhabditis elegans	5829	-

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	O76373	-	-
Mus musculus	Q641K1	-	-

Synonyms

Synonyms	Comment	Organism
CCP1	-	Mus musculus
CCPP-1	-	Caenorhabditis elegans
cytosolic carboxypeptidase CCP1	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	loss of CCP1 in mice causes cerebellar Purkinje cell degeneration. Neuronal degeneration caused by loss of CCP1 in mammals may represent a novel ciliopathy in which cilia are formed but not maintained, depriving the cell of cilia-based signal transduction	Mus musculus
physiological function	CCPP-1 acts as a tubulin deglutamylase that regulates the localization and velocity of kinesin motors, and the structural integrity of microtubules in sensory cilia of a multicellular, living animal	Mus musculus
physiological function	the enzyme regulates the ciliary localization of the kinesin-3 KLP-6 and the polycystin PKD-2 in male-specific sensory neurons in Caenorhabditis elegans. CCPP-1 activity is required for ciliary maintenance but not ciliogenesi	Caenorhabditis elegans

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Release 2023.1 (January 2023)