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Literature summary for 3.4.17.24 extracted from

  • Rogowski, K.; van Dijk, J.; Magiera, M.M.; Bosc, C.; Deloulme, J.C.; Bosson, A.; Peris, L.; Gold, N.D.; Lacroix, B.; Bosch Grau, M.; Bec, N.; Larroque, C.; Desagher, S.; Holzer, M.; Andrieux, A.; Moutin, M.J.; Janke, C.
    A family of protein-deglutamylating enzymes associated with neurodegeneration (2010), Cell, 143, 564-578.
    View publication on PubMed
Search for more literature for 3.4.17.24

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NDL9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
monoglutamyl alpha-tubulin + H2O
-
 Homo sapiens alpha-tubulin + L-Glu
-
 r
monoglutamyl beta-tubulin + H2O
-
 Homo sapiens beta-tubulin + L-Glu
-
 r
additional information isoform CCP5 is a deglutamylase that specifically removes branching point glutamates. CCP5 is the only enzyme that is able to remove tubulin-tyrosine ligase-like protein TTLL4-dependent monoglutamylation. CCP5 removes glutamylation not only from tubulin but also from other substrates that are monoglutamylated by TTLL4. Active CCP5 completely removes monoglutamylation and strongly reduces polyglutamylation of tubulin by TTLL6. Only short side chains are removed, and CCP5 does not generate DELTA2-tubulin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AGBL5
-
 Homo sapiens
CCP5
-
 Homo sapiens
cytosolic carboxypeptidase-like protein 5
-
 Homo sapiens