EC Number   |
General Information |
Reference |
|---|
   3.4.17.24 | malfunction |
CCP5 deficiency does cause male infertility |
758406 |
| 3.4.17.24 | malfunction |
knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature |
757145 |
| 3.4.17.24 | malfunction |
loss of CCP1 in mice causes cerebellar Purkinje cell degeneration. Neuronal degeneration caused by loss of CCP1 in mammals may represent a novel ciliopathy in which cilia are formed but not maintained, depriving the cell of cilia-based signal transduction |
756530 |
| 3.4.17.24 | physiological function |
CCP1 and CCP5 play important roles in zebrafish embryonic development, particularly the development and functioning of cilia. Loss of the deglutamylating enzymes causes developmental defects in zebrafish |
757145 |
| 3.4.17.24 | physiological function |
CCP1-mediated shortening of acidic protein tails might regulate protein-protein and protein-DNA interactions |
757663 |
| 3.4.17.24 | physiological function |
CCP5 is not essential for neuronal survival in mouse. CCP5 is involved in spermatogenesis |
758406 |
| 3.4.17.24 | physiological function |
CCPP-1 acts as a tubulin deglutamylase that regulates the localization and velocity of kinesin motors, and the structural integrity of microtubules in sensory cilia of a multicellular, living animal |
756530 |
| 3.4.17.24 | physiological function |
isoform ccp5 knockdown increases cilia tubulin glutamylation, induces ciliopathy phenotypes, including axis curvature, hydrocephalus, and pronephric cysts, and disrupts multicilia motility. ccp5 knockdown restores tubulin glutamylation and promotes multicilia assembly in intraflagellar transport-deficient zebrafish |
732484 |
| 3.4.17.24 | physiological function |
loss of ccpp-6 gene function, which encodes one of two cytosolic carboxypeptidases, results in elevated levels of ciliary microtubule polyglutamylation. Overexpression of this gene in ciliated cells decreases polyglutamylation signals |
732037 |
| 3.4.17.24 | physiological function |
overexpression of murine CCP5 causes a dramatic loss of microtubule polyglutamylation in cultured mammalian cells. Recombinantly expressed Myc-tagged CCP5 exhibits deglutamylase biochemical activities |
732037 |
