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ATP: GMP phosphotransferase
ATP:GMP phosphotransferase
CASK polypeptide
cf. EC 2.7.11.1, the protein contains a guanylate kinase domain
deoxyguanylate kinase
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guanosine monophosphate kinase
guanosine monophosphate kinase (EcGMPK)
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guanylate kinase (GK)
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guanylate monophosphate kinase
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kinase, guanylate (phosphorylating)
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membrane associated guanylate kinase
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membrane associated guanylate kinase protein
membrane-associated guanylate kinase
membrane-associated guanylate kinases
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post-synaptic density-95 membrane associated guanylate kinase
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postsynaptic density protein-95 SH3 GK
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Staphylococcus aureus guanylate monophosphate kinase
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voltage-gated calcium channel beta1b
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voltage-gated calcium channel beta2a
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additional information
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the enzyme belongs to the post-synaptic density-95 membrane associated guanylate kinase, MAGUK, family of scaffolding proteins,
ATP: GMP phosphotransferase

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ATP: GMP phosphotransferase
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ATP:GMP phosphotransferase

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ATP:GMP phosphotransferase
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ATP:GMP phosphotransferase
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BmGK

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DLG1/SAP97

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GKpm

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GMK

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GMP kinase

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GMPK

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guanosine monophosphate kinase

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guanosine monophosphate kinase
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guanosine monophosphate kinase
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guanylate kinase

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GUK

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MAGUK

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membrane associated guanylate kinase protein

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membrane associated guanylate kinase protein
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membrane associated guanylate kinase protein
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membrane-associated guanylate kinase

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membrane-associated guanylate kinase
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membrane-associated guanylate kinase
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membrane-associated guanylate kinase
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aciclovir (ACV-MP)
?
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?
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
ATP + (R)-ganciclovir phosphonate
?
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?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
ATP + 8-bromoguanosine 5'-monophosphate
ADP + 8-bromoguanosine 5'-diphosphate
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poor substrate
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?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate
ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-diphosphate
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no substrate: 9-(5,5-difluoro-5-phosphonopentyl)guanine 5'-monophosphate
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?
ATP + 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate
ADP + 9-(2-hydroxyethoxymethyl)guanine 5'-diphosphate
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i.e. acyclovir 5'-monophosphate
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?
ATP + 9-(5-phosphonopentyl)guanine
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9-(5,5'-difluoro-5-phosphonopenthyl)guanine is not a substrate
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?
ATP + AMP
2 ADP
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ATP + AMP
ADP + ADP
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very low activity with AMP
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?
ATP + ganciclovir
ADP + ganciclovir phosphate
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ATP + ganciclovir monophosphate
?
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?
ATP + ganciclovir monophosphate
ADP + ganciclovir-diphosphate
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?
ATP + IMP
ADP + IDP
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very poor substrate
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?
GDP + GDP
GTP + GMP
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?
GMP + MgATP2-
MgADP- + GDP
GTP + dAMP
GDP + dADP
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r
GTP + GDP
GMP + guanosine 5'-tetraphosphate
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?
guanosine monophosphate + adenosine triphosphate
guanosine diphosphate + adenosine diphosphate
additional information
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ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid

(R)-ganciclovir phosphonate monophosphate
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i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution
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?
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
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i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution
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?
ATP + 6-thioguanosine 5'-monophosphate

ADP + 8-thioguanosine 5'-diphosphate
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?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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not thiodeoxyguanosine derivative
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?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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?
ATP + 8-azaguanosine 5'-monophosphate

ADP + 8-azaguanosine 5'-diphosphate
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?
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
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?
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
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?
ATP + dGMP

ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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phosphorylation at 48% the rate of GMP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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?
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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?
ATP + dGMP
ADP + dGDP
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low activity, dGMP acts also as inhibitor
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ATP + dGMP
ADP + dGDP
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dGMP is a poor substrate, the Kcat for dGMP is about 22fold lower than that observed for GMP. The value of kcat/Km for dGMP is at least 70fold lower than that of GMP
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ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + dGMP
ADP + dGDP
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r
ATP + GDP

ADP + GTP
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ATP + GDP
ADP + GTP
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ATP + GMP

ADP + GDP
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ATP + GMP
ADP + GDP
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ATP + GMP
ADP + GDP
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specificity
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?, r
ATP + GMP
ADP + GDP
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best substrates
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?
ATP + GMP
ADP + GDP
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no donor substrates are ITP, dGTP, dCTP or dTTP
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?, r
ATP + GMP
ADP + GDP
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dCMP is no acceptor substrate
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?, r
ATP + GMP
ADP + GDP
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dTMP is no acceptor substrate
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?, r
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?, r
ATP + GMP
ADP + GDP
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dAMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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dAMP is no acceptor substrate
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?, r
ATP + GMP
ADP + GDP
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no donor substrates are GTP, CTP, UTP
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?
ATP + GMP
ADP + GDP
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no donor substrates are GTP, CTP, UTP
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?, r
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?, r
ATP + GMP
ADP + GDP
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first step in 'cGMP-cycle' toward re-synthesis of cGMP
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ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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r
ATP + GMP
ADP + GDP
GMP and ATP served as the most effective phosphate acceptor and donor, respectively
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r
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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r
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
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signal transduction
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?
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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signal transduction
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
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nucleoside monophosphate binding site is highly specific for guanine moiety
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?
ATP + GMP
ADP + GDP
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deoxyguanosine, guanosine are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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6-thio-IMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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XMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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dAMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
guanylate kinase is an essential enzyme
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?
ATP + GMP
ADP + GDP
upon substrate binding, the LID and nucleotide-monophosphate-binding domains are brought together and toward the CORE with large concerted movements about the alpha3, helix 3, axis
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?
ATP + GMP
ADP + GDP
guanylate kinase is an essential enzyme
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?
ATP + GMP
ADP + GDP
upon substrate binding, the LID and nucleotide-monophosphate-binding domains are brought together and toward the CORE with large concerted movements about the alpha3, helix 3, axis
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ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
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nucleoside monophosphate binding site is highly specific for guanine moiety
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?
ATP + GMP
ADP + GDP
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deoxyguanosine, guanosine are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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TMP is not an acceptor substrate
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?
ATP + GMP
ADP + GDP
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dCMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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IMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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6-thio-IMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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XMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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dAMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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regulation of cellular adhesion and signal transduction at sites of cell-cell contact
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?
ATP + GMP
ADP + GDP
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CASK construct has no activity
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?
ATP + GMP
ADP + GDP
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PSD-95 construct has no activity
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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r
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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best substrates
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?
ATP + GMP
ADP + GDP
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best substrates
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?
ATP + GMP
ADP + GDP
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IMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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XMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
GMP binding induces conformational changes in non-acetylated N-terminus mutants
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?
ATP + GMP
ADP + GDP
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two specific binding sites: ATP- and GMP-binding site
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
-
regulation of cellular adhesion and signal transduction at sites of cell-cell contact
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?
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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specificity
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?
ATP + GMP
ADP + GDP
-
nucleoside monophosphate binding site is highly specific for guanine moiety
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?
ATP + GMP
ADP + GDP
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deoxyguanosine, guanosine are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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6-thio-IMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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XMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
-
AMP is no acceptor substrate
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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key enzyme of biosynthetic pathway of GTP or dGTP
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r
ATP + GMP
ADP + GDP
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?
ATP + GMP
ADP + GDP
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?
dATP + dGMP

dADP + dGDP
-
as good as ATP
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?
dATP + dGMP
dADP + dGDP
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phosphorylation at 22% the rate of ATP
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?
dATP + dGMP
dADP + dGDP
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?
dATP + dGMP
dADP + dGDP
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?
dATP + dGMP
dADP + dGDP
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-
-
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?
dATP + dGMP
dADP + dGDP
-
-
-
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?
dATP + dGMP
dADP + dGDP
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-
-
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?
dATP + dGMP
dADP + dGDP
-
-
-
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?
dATP + dGMP
dADP + dGDP
-
-
-
-
?
dATP + GMP

dADP + GDP
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as good as ATP
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?
dATP + GMP
dADP + GDP
-
phosphorylation at 81% the rate of ATP
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?
dATP + GMP
dADP + GDP
-
-
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r
dATP + GMP
dADP + GDP
-
-
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?
dATP + GMP
dADP + GDP
-
-
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?
dATP + GMP
dADP + GDP
-
-
-
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?
dATP + GMP
dADP + GDP
-
-
-
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?
dATP + GMP
dADP + GDP
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-