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Information on EC 2.7.4.8 - guanylate kinase
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2.7.4.8 guanylate kinaseIUBMB Comments
dGMP can also act as acceptor, and dATP can act as donor.
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Word Map
- 2.7.4.8
- junction
- synapses
- drosophila
- nmda
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cell-cell
- src
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excitatory
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synapse-associated
- hippocampal
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domain-containing
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magi-1
- adaptor
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spine
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palmitoylated
- n-methyl-d-aspartate
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presynaptic
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glutamatergic
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kinase-like
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adherens
-
pdz-binding
-
zonula
- carma1
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crumbs
- bcl10
-
neurexins
-
discs-large
- dgmp
-
septate
-
occludens
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kinase-associated
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junction-associated
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tcr-induced
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ampars
-
shank
-
mucosa-associated
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card-containing
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neuroligins
- drug development
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
maguk, guanylate kinase, membrane-associated guanylate kinase, maguks, membrane-associated guanylate kinases, guanylate kinase (gk), gmp kinase, membrane associated guanylate kinase, gmpk, cavbeta2a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5'-GMP kinase
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-
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ATP: GMP phosphotransferase
ATP:GMP phosphotransferase
BmGK
CASK polypeptide
cf. EC 2.7.11.1, the protein contains a guanylate kinase domain
deoxyguanylate kinase
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-
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DLG1/SAP97
GKpm
GMK
GMP kinase
GMPK
guanosine monophosphate kinase
guanylate kinase
GUK
kinase, guanylate (phosphorylating)
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-
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MAGUK
membrane associated guanylate kinase protein
membrane-associated guanylate kinase
additional information
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the enzyme belongs to the post-synaptic density-95 membrane associated guanylate kinase, MAGUK, family of scaffolding proteins,
ATP:GMP phosphotransferase
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GMP kinase
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guanosine monophosphate kinase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + GMP = ADP + GDP
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-
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ATP + GMP = ADP + GDP
conformational changes and induced-fit reaction mechanism of the allosteric enzyme, overview
ATP + GMP = ADP + GDP
conformational changes and induced-fit reaction mechanism of the allosteric enzyme, overview
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
Phosphorylation
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:(d)GMP phosphotransferase
dGMP can also act as acceptor, and dATP can act as donor.
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CAS REGISTRY NUMBER
COMMENTARY
9026-59-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
ATP + 8-bromoguanosine 5'-monophosphate
ADP + 8-bromoguanosine 5'-diphosphate
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poor substrate
-
-
?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate
ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-diphosphate
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no substrate: 9-(5,5-difluoro-5-phosphonopentyl)guanine 5'-monophosphate
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-
?
ATP + 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate
ADP + 9-(2-hydroxyethoxymethyl)guanine 5'-diphosphate
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i.e. acyclovir 5'-monophosphate
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-
?
ATP + 9-(5-phosphonopentyl)guanine
?
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9-(5,5'-difluoro-5-phosphonopenthyl)guanine is not a substrate
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-
?
guanosine monophosphate + adenosine triphosphate
guanosine diphosphate + adenosine diphosphate
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
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i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution
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?
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
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i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution
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?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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-
-
-
?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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-
-
-
?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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not thiodeoxyguanosine derivative
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-
?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
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-
-
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?
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
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-
-
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?
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
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-
-
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?
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
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-
-
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?
ATP + dGMP
ADP + dGDP
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low activity, dGMP acts also as inhibitor
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-
?
ATP + dGMP
ADP + dGDP
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dGMP is a poor substrate, the Kcat for dGMP is about 22fold lower than that observed for GMP. The value of kcat/Km for dGMP is at least 70fold lower than that of GMP
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-
?
ATP + GMP
ADP + GDP
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first step in 'cGMP-cycle' toward re-synthesis of cGMP
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-
?
ATP + GMP
ADP + GDP
GMP and ATP served as the most effective phosphate acceptor and donor, respectively
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-
r
ATP + GMP
ADP + GDP
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nucleoside monophosphate binding site is highly specific for guanine moiety
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-
?
ATP + GMP
ADP + GDP
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deoxyguanosine, guanosine are no acceptor substrates
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?
ATP + GMP
ADP + GDP
guanylate kinase is an essential enzyme
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-
?
ATP + GMP
ADP + GDP
upon substrate binding, the LID and nucleotide-monophosphate-binding domains are brought together and toward the CORE with large concerted movements about the alpha3, helix 3, axis
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-
?
ATP + GMP
ADP + GDP
guanylate kinase is an essential enzyme
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-
?
ATP + GMP
ADP + GDP
upon substrate binding, the LID and nucleotide-monophosphate-binding domains are brought together and toward the CORE with large concerted movements about the alpha3, helix 3, axis
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-
?
ATP + GMP
ADP + GDP
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nucleoside monophosphate binding site is highly specific for guanine moiety
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-
?
ATP + GMP
ADP + GDP
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deoxyguanosine, guanosine are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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CMP, UMP are no acceptor substrates
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?
ATP + GMP
ADP + GDP
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regulation of cellular adhesion and signal transduction at sites of cell-cell contact
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?
ATP + GMP
ADP + GDP
GMP binding induces conformational changes in non-acetylated N-terminus mutants
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?
ATP + GMP
ADP + GDP
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two specific binding sites: ATP- and GMP-binding site
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?
ATP + GMP
ADP + GDP
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regulation of cellular adhesion and signal transduction at sites of cell-cell contact
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-
?
ATP + GMP
ADP + GDP
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nucleoside monophosphate binding site is highly specific for guanine moiety
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-
?
ATP + GMP
ADP + GDP
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key enzyme of biosynthetic pathway of GTP or dGTP
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r