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2.7.4.8
drug development
the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance
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660690
2.7.4.8
medicine
GMPK from bacterial pathogens, in which this enzyme is essential, are potential targets for therapeutic inhibition.
672440
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