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Literature summary for 2.7.4.8 extracted from
- Membrane-associated guanylate kinase dynamics reveal regional and developmental specificity of synapse stability (2017), J. Physiol., 595, 1699-1709 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-associated enzyme | Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAGUK | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | removal of membrane-associated guanylate kinase (MAGUK) via RNAi-mediated knockdown in the CA1 hippocampal region in immature animals causes rapid and lasting reductions in glutamatergic transmission. In mature animals, the same manipulation has little acute effect. The hippocampal dentate gyrus, a region with ongoing adult neurogenesis, is sensitive to MAGUK loss in mature animals, behaving like an immature CA1 cell | Rattus norvegicus |
| physiological function | membrane-associated guanylate kinases (MAGUKs) play an essential role localizing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in adult rats | Rattus norvegicus |
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Release 2023.1 (January 2023)
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