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Literature summary for 2.7.4.8 extracted from

  • Ansari, M.; Ahsan, M.; Yasmin, S.; Sahoo, G.; Saini, V.; Das, P.
    In silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors (2017), Gene Rep., 8, 134-143 .
No PubMed abstract available
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Inhibitors

Inhibitors Comment Organism Structure
diospyrin
-
 Leishmania donovani
additional information in silico identification of novel antagonists and binding insights by structural and functional analyses of guanylate kinase of Leishmania donovani and interaction with inhibitors Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GMP Leishmania donovani
-
 ADP + GDP
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GMP
-
 Leishmania donovani ADP + GDP
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0072
-
 pH and temperature not specified in the publication Leishmania donovani diospyrin

General Information

General Information Comment Organism
drug target success for treatment with 5'-guanylic acid in conjunction first-line antileishmanial therapies Leishmania donovani