Reference on EC 2.3.1.293 - meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kapilashrami, K.; Bommineni, G.R.; Machutta, C.A.; Kim, P.; Lai, C.T.; Simmerling, C.; Picart, F.; Tonge, P.J.
Thiolactomycin-based beta-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy
J. Biol. Chem.
288
6045-6052
2013
Mycobacterium tuberculosis
Jayaraman, M.; Rajendra, S.; Ramadas, K.
Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein
Gene
720
144082
2019
Mycobacterium tuberculosis (P9WQD9), Mycobacterium tuberculosis H37Rv (P9WQD9)
Bhatt, A.; Kremer, L.; Dai, A.Z.; Sacchettini, J.C.; Jacobs, W.R.
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis
J. Bacteriol.
187
7596-7606
2005
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc2155
Kremer, L.; Douglas, J.D.; Baulard, A.R.; Morehouse, C.; Guy, M.R.; Alland, D.; Dover, L.G.; Lakey, J.H.; Jacobs, W.R.; Brennan, P.J.; Minnikin, D.E.; Besra, G.S.
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis
J. Biol. Chem.
275
16857-16864
2000
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Schaeffer, M.L.; Agnihotri, G.; Volker, C.; Kallender, H.; Brennan, P.J.; Lonsdale, J.T.
Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB
J. Biol. Chem.
276
47029-47037
2001
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Machutta, C.A.; Bommineni, G.R.; Luckner, S.R.; Kapilashrami, K.; Ruzsicska, B.; Simmerling, C.; Kisker, C.; Tonge, P.J.
Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin
J. Biol. Chem.
285
6161-6169
2010
Mycobacterium tuberculosis
Mdluli, K.; Slayden, R.A.; Zhu, Y.; Ramaswamy, S.; Pan, X.; Mead, D.; Crane, D.D.; Musser, J.M.; Barry, C.E.
Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid
Science
280
1607-1610
1998
Mycobacterium tuberculosis
Luckner, S.; Machutta, C.; Tonge, P.; Kisker, C.
Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin
Structure
17
1004-1013
2009
Mycobacterium tuberculosis (P9WQD9), Mycobacterium tuberculosis H37Rv (P9WQD9)
Slayden, R.; Barry III, C.
The role of KasA and KasB in the biosynthesis of meromycolic acids and isoniazid resistance in Mycobacterium tuberculosis
Tuberculosis
82
149-160
2002
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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