Any feedback?
Literature summary for 2.3.1.293 extracted from
- Development of a scintillation proximity assay for the Mycobacterium tuberculosis KasA and KasB enzymes involved in mycolic acid biosynthesis (2004), Tuberculosis, 84, 353-360 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DMSO | about 130% activity at 2.5% (v/v) DMSO | Mycobacterium tuberculosis |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| thiolactomycin | - |
Mycobacterium tuberculosis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
myristoyl-[acyl-carrier protein] | at pH 6.8 and 37°C | Mycobacterium tuberculosis | |
| 0.005 | - |
biotinylated malonyl-[acyl-carrier protein] | at pH 6.8 and 37°C | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] | - |
? | |
| myristoyl-[acyl-carrier protein] + biotinylated malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-ketoacyl-acyl carrier protein synthase | - |
Mycobacterium tuberculosis |
| KasA | - |
Mycobacterium tuberculosis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0047 | - |
at pH 6.8 and 37°C | Mycobacterium tuberculosis | thiolactomycin | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
