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Literature summary for 2.3.1.293 extracted from

  • Jayaraman, M.; Rajendra, S.; Ramadas, K.
    Structural insight into conformational dynamics of non-active site mutations in KasA A Mycobacterium tuberculosis target protein (2019), Gene, 720, 144082 .
    View publication on PubMed
Search for more literature for 2.3.1.293

Protein Variants

Protein Variants Comment Organism
D66N dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
F413L dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
G269S dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis
G312S dimer non-active site mutant protein displays much more structural flexibility than wild type at the ligand binding site Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis
-
 an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv
-
 an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQD9 cf. EC 2.3.1.41
-
Mycobacterium tuberculosis H37Rv P9WQD9 cf. EC 2.3.1.41
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?
an ultra-long-chain mono-unsaturated acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv an ultra-long-chain mono-unsaturated 3-oxo-fatty acyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl ACP synthase I
-
 Mycobacterium tuberculosis
KasA
-
 Mycobacterium tuberculosis