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Information on EC - beta-ketoacyl-[acyl-carrier-protein] synthase II

for references in articles please use BRENDA:EC2.3.1.179
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EC Tree
IUBMB Comments
Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and bacteria. While the substrate specificity of this enzyme is very similar to that of EC, beta-ketoacyl-[acyl-carrier-protein] synthase I, it differs in that palmitoleoyl-[acyl-carrier protein] is not a good substrate of EC but is an excellent substrate of this enzyme [1,2]. The fatty-acid composition of Escherichia coli changes as a function of growth temperature, with the proportion of unsaturated fatty acids increasing with lower growth temperature. This enzyme controls the temperature-dependent regulation of fatty-acid composition, with mutants lacking this acivity being deficient in the elongation of palmitoleate to cis-vaccenate at low temperatures [3,4].
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a (Z)-hexadec-9-enoyl-[acyl-carrier protein]
a (Z)-3-oxooctadec-11-enoyl-[acyl-carrier protein]
kasii, kas ii, fabf1, beta-ketoacyl-acp synthase ii, fabb/f, fatty acid synthesis type ii, 3-ketoacyl-acp synthase ii, beta-ketoacyl-acyl carrier protein synthase ii, kas-ii, beta-ketoacyl synthase ii, more
a (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadec-11-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein]
show the reaction diagram