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Literature summary for 2.3.1.179 extracted from

  • Wang, Y.; Ma, S.
    Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents (2013), ChemMedChem, 8, 1589-1608.
    View publication on PubMed
Search for more literature for 2.3.1.179

Application

Application Comment Organism
drug development fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis and represent increasingly promising targets for the discovery of antibacterial agents with different mechanisms of action Staphylococcus aureus
drug development fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis and represent increasingly promising targets for the discovery of antibacterial agents with different mechanisms of action Haemophilus influenzae
drug development fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis and represent increasingly promising targets for the discovery of antibacterial agents with different mechanisms of action Enterococcus faecalis

Inhibitors

Inhibitors Comment Organism Structure
1,3-dichloro-7-(2,4-dihydroxy-6-methylphenyl)-2,4,6,9-tetrahydroxy-12,12-dimethyltetracen-5(12H)-one i.e. fasamycin B Enterococcus faecalis
1-chloro-7-(2,4-dihydroxy-6-methylphenyl)-2,4,6,9-tetrahydroxy-12,12-dimethyltetracen-5(12H)-one i.e. fasamycin A Enterococcus faecalis
2-[(2R)-4-ethyl-3-hydroxy-2-[(1E)-2-methylbuta-1,3-dien-1-yl]-5-oxo-2,5-dihydrothiophen-2-yl]acetamide
-
 Enterococcus faecalis
5-chloro-2-(2,4-dichlorophenoxy)phenol Triclosan Haemophilus influenzae
5-chloro-2-(2,4-dichlorophenoxy)phenol Triclosan Staphylococcus aureus
cerulenin originally isolated from the fungus Cephalosporium caerulensand, an irreversible inhibitor of FabF Enterococcus faecalis
cerulenin originally isolated from the fungus Cephalosporium caerulensand, an irreversible inhibitor of FabF Haemophilus influenzae
cerulenin originally isolated from the fungus Cephalosporium caerulensand, an irreversible inhibitor of FabF Staphylococcus aureus
fasamycin A
-
 Staphylococcus aureus
fasamycin B
-
 Staphylococcus aureus
additional information inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition Enterococcus faecalis
additional information inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition Haemophilus influenzae
additional information inhibitors of bacterial FASII can act as potential antibacterial agents, structure-activity relationships of the inhibitors that mainly target beta-ketoacyl-ACP synthase, beta-ketoacyl-ACP reductase, beta-hydroxyacyl-ACP dehydratase, and enoyl-ACP reductase, overview. Screening of phomalenic acids for enzyme inhibition Staphylococcus aureus
phomallenic acid C
-
 Haemophilus influenzae
phomallenic acid C
-
 Staphylococcus aureus
platencin A1 also active against FabH, EC 2.3.1.180 Enterococcus faecalis
platencin A1 also active against FabH, EC 2.3.1.180 Haemophilus influenzae
platencin A1 also active against FabH, EC 2.3.1.180 Staphylococcus aureus
thiolactomycin
-
 Enterococcus faecalis
thiolactomycin
-
 Haemophilus influenzae
thiolactomycin
-
 Staphylococcus aureus
Tü3010
-
 Haemophilus influenzae
Tü3010
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Haemophilus influenzae
-
-
-
Staphylococcus aureus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadec-11-enoyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] the enzyme catalyzes the Claisen condensation reaction by a ping-pong mechanism Enterococcus faecalis
a

Synonyms

Synonyms Comment Organism
FASII
-
 Staphylococcus aureus
FASII
-
 Haemophilus influenzae
FASII
-
 Enterococcus faecalis
fatty acid synthesis type II
-
 Staphylococcus aureus
fatty acid synthesis type II
-
 Haemophilus influenzae
fatty acid synthesis type II
-
 Enterococcus faecalis

General Information

General Information Comment Organism
physiological function fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis Staphylococcus aureus
physiological function fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis Haemophilus influenzae
physiological function fatty acid synthesis type II system enzymes are essential for bacterial membrane lipid biosynthesis. All FASII systems have initiation and elongation condensing enzymes which can catalyze the Claisen condensation of an acyl donor and malonyl-ACP to form a beta-ketoacyl-ACP Enterococcus faecalis