EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
2.3.1.179 | -999 |
- |
more |
IC50 for platencin is 0.00195 ng/ml, IC50 for platensimycin is 0.00013 ng/ml |
676903 |
2.3.1.179 | 0.000048 |
- |
platensimycin |
from Streptomyces platensis, IC50: 48 nM, anti-bacterial effect is exerted through the selective targeting of beta-ketoacyl-[acyl-carrier-protein] synthase I/II, FabF/B, in the synthetic pathway of fatty acids, platensimycin interacts specifically with th |
676148 |
2.3.1.179 | 0.000097 |
- |
dihydroplatensimycin |
IC50: 97 nM |
676148 |
2.3.1.179 | 0.000113 |
- |
platencin |
exhibits a broad-spectrum Gram-positive antibacterial activity through inhibition of fatty acid biosynthesis, targets the two essential proteins, beta-ketoacyl-[acyl carrier protein] synthase II and III, i.e. FabF and FabH, FabF IC50: 113 nM, overview |
676903 |
2.3.1.179 | 0.00016 |
- |
platensimycin |
from Streptomyces platensis, IC50: 160 nM, anti-bacterial effect is exerted through the selective targeting of beta-ketoacyl-[acyl-carrier-protein] synthase I/II, FabF/B, in the synthetic pathway of fatty acids, platensimycin interacts specifically with t |
676148 |
2.3.1.179 | 0.00029 |
- |
platensimycin |
from a strain of Streptomyces platensis MA7339, specifically targets FabF, IC50: 290 nM, exhibits Gram-positive antibacterial activity |
676903 |
2.3.1.179 | 1.1 |
- |
thiolactomycin |
binding structure with mutant C163Q, IC50: 1.1 mM |
676148 |