Reference on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase and Organism(s) Homo sapiens and UniProt Accession O60725
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Park, S.H.; Lee, H.W.
Inhibition of C-terminal O-methyltransferase by a rat liver cytosolic peptide
Arch. Pharm. Res.
17
354-359
1994
Homo sapiens, Rattus norvegicus
-
Klein, Z.; Ben-Baruch, G.; Marciano, D.; Solomon, R.; Altaras, M.; Kloog, Y.
Characterization of the prenylated protein methyltransferase in human endometrial carcinoma
Biochim. Biophys. Acta
1226
330-336
1994
Homo sapiens
Pillinger, M.H.; Volker, C.; Stock, J.B.; Weissmann, G.; Philips, M.R.
Characterization of a plasma membrane-associated prenylcysteine-directed a carboxyl methyltransferase in human neutrophils
J. Biol. Chem.
269
1486-1492
1994
Homo sapiens
Ma, Y.T.; Shi, Y.Q.; Lim, Y.H.; McGrail, S.H.; Ware, J.A.; Rando, R.R.
Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase
Biochemistry
33
5414-5420
1994
Homo sapiens
Hong, K.M.; Choi, Y.B.; Hong, J.H.; Chang, H.S.; Rhee, K.I.; Park, H.; Paik, M.K.
Cysteine carboxyl O-methylation of human placental 23 kDa protein
Exp. Mol. Med.
31
30-35
1999
Homo sapiens
Van Dessel, G.A.F.; De Busser, H.M.; Lagrou, A.R.
Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells
Int. J. Biochem. Cell Biol.
34
477-486
2002
Homo sapiens
Choy, E.; Philips, M.
Expression and activity of human prenylcysteine-directed carboxyl methyltransferase
Methods Enzymol.
325
101-114
2000
Homo sapiens
Baron, R.A.; Casey, P.J.
Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt)
BMC Biochem.
5
19
2004
Homo sapiens
Papaharalambus, C.; Sajjad, W.; Syed, A.; Zhang, C.; Bergo, M.O.; Alexander, R.W.; Ahmad, M.
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase
J. Biol. Chem.
280
18790-18796
2005
Homo sapiens
Donelson, J.L.; Hodges, H.B.; Macdougall, D.D.; Henriksen, B.S.; Hrycyna, C.A.; Gibbs, R.A.
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Bioorg. Med. Chem. Lett.
16
4420-4423
2006
Homo sapiens
Leow, J.L.; Baron, R.; Casey, P.J.; Go, M.L.
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Bioorg. Med. Chem. Lett.
17
1025-1032
2007
Homo sapiens
Anderson, J.L.; Henriksen, B.S.; Gibbs, R.A.; Hrycyna, C.A.
The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors
J. Biol. Chem.
280
29454-29461
2005
Homo sapiens, Saccharomyces cerevisiae
Winter-Vann, A.M.; Baron, R.A.; Wong, W.; dela Cruz, J.; York, J.D.; Gooden, D.M.; Bergo, M.O.; Young, S.G.; Toone, E.J.; Casey, P.J.
A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells
Proc. Natl. Acad. Sci. USA
102
4336-4341
2005
Homo sapiens
Cushman, I.; Casey, P.J.
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration
J. Biol. Chem.
284
27964-27973
2009
Homo sapiens
Wright, L.P.; Court, H.; Mor, A.; Ahearn, I.M.; Casey, P.J.; Philips, M.R.
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe
Mol. Cell. Biol.
29
1826-1833
2009
Homo sapiens
Buchanan, M.S.; Carroll, A.R.; Fechner, G.A.; Boyle, A.; Simpson, M.; Addepalli, R.; Avery, V.M.; Forster, P.I.; Guymer, G.P.; Cheung, T.; Chen, H.; Quinn, R.J.
Small-molecule inhibitors of the cancer target, isoprenylcysteine carboxyl methyltransferase, from Hovea parvicalyx
Phytochemistry
69
1886-1889
2008
Homo sapiens
Bergman, J.A.; Hahne, K.; Song, J.; Hrycyna, C.A.; Gibbs, R.A.
S-farnesyl-thiopropionic acid (FTPA) triazoles as potent inhibitors of isoprenylcysteine carboxyl methyltransferase
ACS Med. Chem. Lett.
3
15-19
2012
Homo sapiens
Bergman, J.A.; Hahne, K.; Hrycyna, C.A.; Gibbs, R.A.
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors
Bioorg. Med. Chem. Lett.
21
5616-5619
2011
Homo sapiens
Majmudar, J.D.; Hodges-Loaiza, H.B.; Hahne, K.; Donelson, J.L.; Song, J.; Shrestha, L.; Harrison, M.L.; Hrycyna, C.A.; Gibbs, R.A.
Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization
Bioorg. Med. Chem.
20
283-295
2012
Homo sapiens
Cushman, I.; Casey, P.J.
RHO methylation matters: a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion
Cell Adh. Migr.
5
11-15
2011
Homo sapiens
Go, M.L.; Leow, J.L.; Gorla, S.K.; Schueller, A.P.; Wang, M.; Casey, P.J.
Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase
J. Med. Chem.
53
6838-6850
2010
Homo sapiens
Judd, W.R.; Slattum, P.M.; Hoang, K.C.; Bhoite, L.; Valppu, L.; Alberts, G.; Brown, B.; Roth, B.; Ostanin, K.; Huang, L.; Wettstein, D.; Richards, B.; Willardsen, J.A.
Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)
J. Med. Chem.
54
5031-5047
2011
Homo sapiens
Hahne, K.; Vervacke, J.S.; Shrestha, L.; Donelson, J.L.; Gibbs, R.A.; Distefano, M.D.; Hrycyna, C.A.
Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes
Biochem. Biophys. Res. Commun.
423
98-103
2012
Homo sapiens, Saccharomyces cerevisiae
Ramanujulu, P.M.; Yang, T.; Yap, S.Q.; Wong, F.C.; Casey, P.J.; Wang, M.; Go, M.L.
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt)
Eur. J. Med. Chem.
63
378-386
2013
Homo sapiens
Diver, M.M.; Long, S.B.
Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites
J. Biol. Chem.
289
26007-26020
2014
Anopheles gambiae (Q7PXA7), Anopheles gambiae, Homo sapiens
Bhadoriya, K.; Sharma, M.; Jain, S.
Pharmacophore modeling and atom-based 3D-QSAR studies on amino derivatives of indole as potent isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitors
J. Mol. Struct.
1081
466-476
2015
Homo sapiens
-
Teh, J.T.; Zhu, W.L.; Ilkayeva, O.R.; Li, Y.; Gooding, J.; Casey, P.J.; Summers, S.A.; Newgard, C.B.; Wang, M.
Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism
Oncogene
34
3296-3304
2015
Homo sapiens
Liu, Q.; Chen, J.; Fu, B.; Dai, J.; Zhao, Y.; Lai, L.
Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation
Biochem. Biophys. Res. Commun.
501
556-562
2018
Homo sapiens (A0A024R4F6), Homo sapiens
Zhu, Y.; Hu, Q.; Li, H.
Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation
Biochem. Biophys. Res. Commun.
516
784-789
2019
Homo sapiens (A0A024R4F6)
Borini Etichetti, C.; Di Benedetto, C.; Rossi, C.; Baglioni, M.V.; Bicciato, S.; Del Sal, G.; Menacho-Marquez, M.; Girardini, J.
Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor
J. Biol. Chem.
294
5060-5073
2019
Homo sapiens
Butler, K.V.; Bohn, K.; Hrycyna, C.A.; Jin, J.
Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferase
MedChemComm
7
1016-1021
2016
Homo sapiens (O60725), Homo sapiens
Lau, H.Y.; Tang, J.; Casey, P.J.; Wang, M.
Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms
Oncogene
36
3934-3942
2017
Homo sapiens (O60725), Homo sapiens
