Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cysmethynil | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | Homo sapiens | - |
S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA-MB-231 cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine | - |
Homo sapiens | S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Homo sapiens |
isoprenylcysteine carboxylmethyltransferase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition reduces the function of mitochondrial oxidative phosphorylation in cancer cells. Enzyme inhibition decreases cellular ATP and depletes critical tricarboxylic acid cycle metabolites, leading to suppression of cell anabolism and growth, and marked autophagy | Homo sapiens |
physiological function | the enzyme regulates mitochondrial respiration and cancer cell metabolism | Homo sapiens |