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BRENDA support

Information on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

for references in articles please use BRENDA:EC2.1.1.100

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IUBMB Comments

C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
ste14p, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, prenylated protein methyltransferase, isoprenylated protein methyltransferase, protein-s-isoprenylcysteine o-methyltransferase, isoprenylcysteine methylesterase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
show the reaction diagram