Literature summary for 2.1.1.100 extracted from

Leow, J.L.; Baron, R.; Casey, P.J.; Go, M.L.
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase (2007), Bioorg. Med. Chem. Lett., 17, 1025-1032.

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Application

Application	Comment	Organism
analysis	approaches to establish the quantitative structureactivity relationship of indoloacetamides as inhibitors of ICMT	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	good inhibitory activity is determined largely by the characteristics of the substituent attached to the indole nitrogen, which should be a lipophilic residue with fairly wide dimensions. In contrast, the substituted phenyl ring attached to the indole ring must be of limited dimensions and lipophilicity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Icmt	-	Homo sapiens
isoprenylcysteine carboxyl methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)