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Literature summary for 2.1.1.100 extracted from
- Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor (2019), J. Biol. Chem., 294, 5060-5073 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a correlation exists between p53 status and ICMT expression in breast and lung cancers. ICMT overexpression is correlated with negative clinical outcomes | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MDA-MB-231 cell | - |
Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | wild-type p53 represses ICMT transcription. The repressive effect of wild-type p53 is localized to the -209 and -14 region on the ICMT promoter, and p53 is recruited to this region. p53 mutants show a positive effect on ICMT expression | additional information |
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