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Literature summary for 2.1.1.100 extracted from

  • Bhadoriya, K.; Sharma, M.; Jain, S.
    Pharmacophore modeling and atom-based 3D-QSAR studies on amino derivatives of indole as potent isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitors (2015), J. Mol. Struct., 1081, 466-476.
No PubMed abstract available
Search for more literature for 2.1.1.100

Inhibitors

Inhibitors Comment Organism Structure
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1H-indole
-
 Homo sapiens
1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(piperidin-1-yl)methyl]-1H-indole
-
 Homo sapiens
1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
-
 Homo sapiens
2-(1-octyl-1H-indol-3-yl)acetamide
-
 Homo sapiens
2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide
-
 Homo sapiens
2-[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[1-[(2E,6E)-2,6-dimethylocta-2,6-dien-1-yl]-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]-N,N-diethylacetamide
-
 Homo sapiens
2-[5-(3-ethylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethan-1-one
-
 Homo sapiens
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethan-1-one
-
 Homo sapiens
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one
-
 Homo sapiens
2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-methylphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(3-methylphenyl)-1H-indol-3-yl]acetamide
-
 Homo sapiens
2-[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
3-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]propanamide
-
 Homo sapiens
5-(3-methylphenyl)-1-octyl-1H-indole-3-carboxamide
-
 Homo sapiens
5-(3-methylphenyl)-1-octyl-3-[(piperidin-1-yl)methyl]-1H-indole
-
 Homo sapiens
5-(3-methylphenyl)-1-octyl-3-[(pyrrolidin-1-yl)methyl]-1H-indole
-
 Homo sapiens
5-(3-methylphenyl)-3-[(4-methylpiperazin-1-yl)methyl]-1-octyl-1H-indole
-
 Homo sapiens
5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1-octyl-1H-indole
-
 Homo sapiens
methyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate
-
 Homo sapiens
N,N-diethyl-2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
N,N-diethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
N,N-dimethyl-1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
-
 Homo sapiens
N,N-dimethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
-
 Homo sapiens
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-ethyl-N-[[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
-
 Homo sapiens
N-methyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]propan-2-amine
-
 Homo sapiens
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-(propan-2-yl)propan-2-amine
-
 Homo sapiens
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-propylpropan-1-amine
-
 Homo sapiens
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]acetamide
-
 Homo sapiens
N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]methanesulfonamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine Homo sapiens
-
 S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
 Homo sapiens S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Synonyms

Synonyms Comment Organism
Icmt
-
 Homo sapiens
isoprenylcysteine carboxyl methyltransferase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
 pH and temperature not specified in the publication Homo sapiens 5-(3-methylphenyl)-1-octyl-3-[(pyrrolidin-1-yl)methyl]-1H-indole
0.0006
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0006
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0007
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0007
-
 pH and temperature not specified in the publication Homo sapiens 1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
0.0007
-
 pH and temperature not specified in the publication Homo sapiens 5-(3-methylphenyl)-1-octyl-3-[(piperidin-1-yl)methyl]-1H-indole
0.0008
-
 pH and temperature not specified in the publication Homo sapiens N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-propylpropan-1-amine
0.0008
-
 pH and temperature not specified in the publication Homo sapiens N,N-diethyl-2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0009
-
 pH and temperature not specified in the publication Homo sapiens N-methyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]propan-2-amine
0.0009
-
 pH and temperature not specified in the publication Homo sapiens 5-(3-methylphenyl)-3-[(4-methylpiperazin-1-yl)methyl]-1-octyl-1H-indole
0.001
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.001
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.001
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]-N,N-diethylacetamide
0.0011
-
 pH and temperature not specified in the publication Homo sapiens 2-[1-[(2E,6E)-2,6-dimethylocta-2,6-dien-1-yl]-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
0.0012
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one
0.0012
-
 pH and temperature not specified in the publication Homo sapiens 3-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]propanamide
0.0012
-
 pH and temperature not specified in the publication Homo sapiens N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]methanesulfonamide
0.0013
-
 pH and temperature not specified in the publication Homo sapiens N,N-dimethyl-1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine
0.0013
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-ethylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0014
-
 pH and temperature not specified in the publication Homo sapiens N,N-diethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0015
-
 pH and temperature not specified in the publication Homo sapiens N,N-dimethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0015
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0017
-
 pH and temperature not specified in the publication Homo sapiens N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-(propan-2-yl)propan-2-amine
0.0017
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethan-1-one
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide
0.0018
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethan-1-one
0.0018
-
 pH and temperature not specified in the publication Homo sapiens N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]acetamide
0.0019
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide
0.002
-
 pH and temperature not specified in the publication Homo sapiens 1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1H-indole
0.0021
-
 pH and temperature not specified in the publication Homo sapiens 1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(piperidin-1-yl)methyl]-1H-indole
0.0024
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]methyl]ethanamine
0.0025
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-indol-3-yl]acetamide
0.0027
-
 pH and temperature not specified in the publication Homo sapiens 5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1-octyl-1H-indole
0.0041
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine
0.0065
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-octyl-1H-indol-3-yl)acetamide
0.007
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]acetamide
0.0077
-
 pH and temperature not specified in the publication Homo sapiens 2-[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide
0.03
-
 pH and temperature not specified in the publication Homo sapiens 5-(3-methylphenyl)-1-octyl-1H-indole-3-carboxamide
0.033
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-methylphenyl)-1H-indol-3-yl]acetamide
0.035
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
0.067
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine
0.069
-
 pH and temperature not specified in the publication Homo sapiens 2-[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]acetamide
0.076
-
 pH and temperature not specified in the publication Homo sapiens methyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate