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Literature summary for 2.1.1.100 extracted from

  • Butler, K.V.; Bohn, K.; Hrycyna, C.A.; Jin, J.
    Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferase (2016), MedChemComm, 7, 1016-1021 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane competitive with the prenylated peptide substrate, N-acetyl-S-farnesyl cysteine and non-competitive with SAM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60725
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0011
-
 4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane substrate N-acetyl-S-farnesyl cysteine, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0029
-
 4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane substrate S-adenosyl-L-methionine, pH not specified in the publication, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane