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Information on EC 1.5.99.4 - nicotine dehydrogenase

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IUBMB Comments
A metalloprotein (FMN). The enzyme can act on both the naturally found (S)-enantiomer and the synthetic (R)-enantiomer of nicotine, with retention of configuration in both cases .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor
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; A metalloprotein (FMN). Acts on both (R)- and (S)-isomers
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