Ligand reduced acceptor

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Basic Ligand Information

Molecular Structure
Picture of reduced acceptor (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H2R
reduced acceptor
RKBSROANWBGWFW-UHFFFAOYSA-N
Synonyms:
acceptor-H2, acceptorH2, AH2, Donor, reduced acceptor (overall reaction)

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (193 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phosphonoacetaldehyde + reduced acceptor = 2-hydroxyethylphosphonate + acceptor
show the reaction diagram
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
show the reaction diagram
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L-tyrosine + O2 + AH2 = L-3,4-dihydroxyphenylalanine + H2O + A
show the reaction diagram
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4,4-dimethyl-zymosterol + reduced acceptor + O2 = 4-hydroxymethyl,4-methyl-zymosterol + acceptor + H2O
show the reaction diagram
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(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + reduced acceptor + O2 = (9Z,12Z)-hexadeca-9,12,15-trienoyl-CoA + acceptor + H2O
show the reaction diagram
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(11Z)-hexadec-11-enoyl-CoA + reduced acceptor + O2 = (10E,12Z)-hexadeca-10,12-dienoyl-CoA + acceptor + H2O
show the reaction diagram
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myristoyl-CoA + reduced acceptor + O2 = (E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
show the reaction diagram
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linoleate + reduced acceptor + O2 = crepenynate + acceptor + H2O
show the reaction diagram
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androst-4-ene-3,17-dione + AH2 + O2 = 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O
show the reaction diagram
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4-methoxybenzoate + AH2 + O2 = 4-hydroxybenzoate + formaldehyde + A + H2O
show the reaction diagram
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O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
show the reaction diagram
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phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O
show the reaction diagram
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Latia luciferin + AH2 + O2 = oxidized Latia luciferin + CO2 + formate + A + H2O + hnu
show the reaction diagram
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progesterone + AH2 + O2 = 9alpha-hydroxyprogesterone + A + H2O
show the reaction diagram
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thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O
show the reaction diagram
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cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
show the reaction diagram
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ammonia + AH2 + O2 = NH2OH + A + H2O
show the reaction diagram
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[(1->4)-beta-D-glucosyl]n+m + AH2 + O2 = [(1->4)-beta-D-glucosyl]m-1-(1->4)-D-glucono-1,5-lactone + [(1->4)-beta-D-glucosyl]n + A + H2O
show the reaction diagram
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starch + AH2 + O2 = aldonic acid-terminated malto-oligosaccharides + A + H2O
show the reaction diagram
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cyclooctat-9-en-7-ol + reduced acceptor + O2 = cyclooctat-9-ene-5,7-diol + acceptor + H2O
show the reaction diagram
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cyclooctat-9-ene-5,7-diol + reduced acceptor + O2 = cyclooctatin + acceptor + H2O
show the reaction diagram
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superoxide + reduced acceptor + 2 H+ = H2O2 + oxidized acceptor
show the reaction diagram
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2,3-epoxyphylloquinone + AH2 = phylloquinone + A + ?
show the reaction diagram
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epoxyqueuosine34 in tRNA + reduced acceptor = queuosine34 in tRNA + acceptor + H2O
show the reaction diagram
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CO2 + methanofuran + reduced acceptor = formylmethanofuran + H2O + acceptor
show the reaction diagram
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arsenate + reduced acceptor = arsenite + acceptor
show the reaction diagram
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arsenate + reduced acceptor = arsenite + acceptor
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crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor
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fumarate + reduced acceptor = succinate + acceptor
show the reaction diagram
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2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate + reduced acceptor = 2,3-bis-O-phytanyl-sn-glycerol 1-phosphate + acceptor
show the reaction diagram
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red chlorophyll catabolite + reduced acceptor = primary fluorescent chlorophyll catabolite + oxidized acceptor
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chlorophyllide a + AH2 + ATP + H2O = 3-deacetyl-3-vinylbacteriochlorophyllide a + A + ADP + phosphate
show the reaction diagram
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2-butenoyl-CoA + reduced acceptor = butanoyl-CoA + acceptor
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all-trans-retinol + reduced acceptor = all-trans-13,14-dihydroretinol + acceptor
show the reaction diagram
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menaquinone-7 + reduced acceptor = ?
show the reaction diagram
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an archaeal alpha-reduced dolichyl phosphate + reduced acceptor = an archaeal alpha,omega-reduced dolichyl phosphate + acceptor
show the reaction diagram
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7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor
show the reaction diagram
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adenylyl sulfate + reduced acceptor = AMP + sulfite + acceptor
show the reaction diagram
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nitrate + reduced acceptor = nitrite + acceptor
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selenate + reduced acceptor = selenite + H2O + acceptor
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2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricin + reduced acceptor = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + N-acetylphosphinothricin + oxidized acceptor
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a [protein]-S-sulfanyl-L-cysteine + uridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
show the reaction diagram
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a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
show the reaction diagram
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molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor
show the reaction diagram
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5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor
show the reaction diagram
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dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-alpha-D-glucopyranose + NH3 + L-methionine + 5'-deoxyadenosine + acceptor
show the reaction diagram
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L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (148 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-sorbitol + acceptor = L-sorbose + reduced acceptor
show the reaction diagram
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polyvinyl alcohol + oxidized acceptor = polyvinyl alcohol containing oxo-groups + reduced acceptor
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glycolate + acceptor = glyoxylate + reduced acceptor
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sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor
show the reaction diagram
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(S)-malate + acceptor = oxaloacetate + reduced acceptor
show the reaction diagram
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D-fructose + acceptor = 5-dehydro-D-fructose + reduced acceptor
show the reaction diagram
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(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
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D-sorbitol + acceptor = L-sorbose + reduced acceptor
show the reaction diagram
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L-sorbose + acceptor = L-sorbosone + reduced acceptor
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D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor
show the reaction diagram
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(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
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(R)-lactate + acceptor = pyruvate + reduced acceptor
show the reaction diagram
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pyridoxine + acceptor = isopyridoxal + reduced acceptor
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ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor
show the reaction diagram
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queuosine34 in tRNA + acceptor + H2O = epoxyqueuosine34 in tRNA + reduced acceptor
show the reaction diagram
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formate + acceptor = CO2 + reduced acceptor
show the reaction diagram
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1-butanol + acceptor = butanal + reduced acceptor
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D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor
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arsenite + acceptor = arsenate + reduced acceptor
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arsenite + acceptor = arsenate + reduced acceptor
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beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor
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3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor
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trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor
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(S)-dihydroorotate + acceptor = orotate + reduced acceptor
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15-cis-phytoene + acceptor = 9,15,9'-tricis-zeta-carotene + reduced acceptor
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isovaleryl-CoA + acceptor = 3-methylcrotonyl-CoA + reduced acceptor
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lauroyl-CoA + acceptor = 2-dodecenoyl-CoA + reduced acceptor
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(S)-dihydroorotate + acceptor = orotate + reduced acceptor
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all-trans-zeta-carotene + 2 acceptor = all-trans-lycopene + 2 reduced acceptor
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15-cis-phytoene + 5 acceptor = all-trans-3,4-didehydrolycopene + 5 reduced acceptor
show the reaction diagram
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2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
show the reaction diagram
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3-(methylthio)propionyl-CoA + acceptor = (2E)-3-(methylthio)prop-2-enoyl-CoA + reduced acceptor
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3-phenylpropionyl-CoA + acceptor = cinnamoyl-CoA + reduced acceptor
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2-phenylethylamine + 2 H2O + 2 acceptor = 2-phenylacetic acid + NH3 + 2 reduced acceptor
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aromatic amines + acceptor + H2O = ? + reduced acceptor + NH3
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taurine + H2O + acceptor = sulfoacetaldehyde + NH3 + reduced acceptor
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cis-4-hydroxy-D-proline + acceptor = (4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + reduced acceptor
show the reaction diagram
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sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor
show the reaction diagram
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N,N-dimethylglycine + tetrahydropteroylpentaglutamate + acceptor = sarcosine + 5,10-methylene tetrahydropteroylpentaglutamate + reduced acceptor
show the reaction diagram
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N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced acceptor
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5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor
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N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor
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NADH + H+ + acceptor = NAD+ + reduced acceptor
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nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor
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N2O + acceptor + H2O = NO + reduced acceptor
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hydroxylamine + 2 acceptor + H2O = nitrite + 2 reduced acceptor + H+
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hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O = sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+
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protein-dithiol + oxidized acceptor = protein-disulfide + reduced acceptor
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ATP + [TtuB sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + 5-methyluridine54 in tRNA + acceptor = AMP + diphosphate + 5-methyl-2-thiouridine54 in tRNA + [TtuB sulfur-carrier protein] + reduced acceptor
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (496 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
phenylpyruvate + reduced acceptor = phenyl-(R)-lactate + acceptor
show the reaction diagram
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phosphonoacetaldehyde + reduced acceptor = 2-hydroxyethylphosphonate + acceptor
show the reaction diagram
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
show the reaction diagram
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testosterone + reduced acceptor + O2 = 15beta-hydroxytestosterone + oxidized acceptor + H2O
show the reaction diagram
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(24Z)-5alpha-stigmast-7,24(241)-dien-3beta-ol + O2 + reduced acceptor = (24Z)-stigmasta-5,7,24(241)-trien-3-beta-ol + acceptor + H2O
show the reaction diagram
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myristoyl-CoA + reduced acceptor + O2 = (E)-11-tetradecenoyl-CoA + acceptor + 2 H2O
show the reaction diagram
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oleic acid + reduced acceptor + O2 = linoleic acid + acceptor + H2O
show the reaction diagram
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O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
show the reaction diagram
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phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O
show the reaction diagram
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Latia luciferin + AH2 + O2 = oxidized Latia luciferin + CO2 + formate + A + H2O + hnu
show the reaction diagram
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thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O
show the reaction diagram
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cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
show the reaction diagram
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ammonia + AH2 + O2 = NH2OH + A + H2O
show the reaction diagram
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(+)-larreatricin + O2 + AH2 = (+)-3-hydroxylarreatricin + A + H2O
show the reaction diagram
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[(1->4)-N-acetyl-beta-D-glucosaminyl]n+m + reduced acceptor + O2 = [(1->4)-N-acetyl-beta-D-glucosaminyl]m-1-(1->4)-N-acetyl-2-deoxy-2-amino-D-glucono-1,5-lactone + [(1->4)-N-acetyl-beta-D-glucosaminyl]n + acceptor + H2O
show the reaction diagram
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starch + AH2 + O2 = aldonic acid-terminated malto-oligosaccharides + A + H2O
show the reaction diagram
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cellulose + reduced acceptor + O2 = ? + oxidized acceptor + H2O
show the reaction diagram
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cyclooctat-9-en-7-ol + reduced acceptor + O2 = cyclooctat-9-ene-5,7-diol + acceptor + H2O
show the reaction diagram
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cyclooctat-9-ene-5,7-diol + reduced acceptor + O2 = cyclooctatin + acceptor + H2O
show the reaction diagram
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2,3-epoxyphylloquinone + AH2 = phylloquinone + A + ?
show the reaction diagram
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epoxyqueuosine34 in tRNA + reduced acceptor = queuosine34 in tRNA + acceptor + H2O
show the reaction diagram
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CO2 + methanofuran + reduced acceptor = formylmethanofuran + H2O + acceptor
show the reaction diagram
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arsenate + reduced acceptor = arsenite + acceptor
show the reaction diagram
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crotonyl-CoA + reduced acceptor = butyryl-CoA + oxidized acceptor
show the reaction diagram
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fumarate + reduced acceptor = succinate + acceptor
show the reaction diagram
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chlorophyllide a + AH2 + ATP + H2O = 3-deacetyl-3-vinylbacteriochlorophyllide a + A + ADP + phosphate
show the reaction diagram
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quinoline 8-carboxylic acid + reduced acceptor = ?
show the reaction diagram
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menaquinone-9 + reduced acceptor = beta-dihydromenaquinone-9 + acceptor
show the reaction diagram
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menaquinone-7 + reduced acceptor = ?
show the reaction diagram
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an archaeal alpha-reduced dolichyl phosphate + reduced acceptor = an archaeal alpha,omega-reduced dolichyl phosphate + acceptor
show the reaction diagram
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7,8-dihydromethanopterin + reduced acceptor = 5,6,7,8-tetrahydromethanopterin + oxidized acceptor
show the reaction diagram
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chlorate + reduced acceptor = chlorite + acceptor
show the reaction diagram
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hydroxylamine + reduced acceptor = ammonia + oxidized acceptor
show the reaction diagram
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[arylsulfatase A]-L-cysteine69 + O2 + reduced acceptor = [arylsulfatase A]-Calpha-formylglycine69 + hydrogen sulfide + acceptor
show the reaction diagram
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adenylyl sulfate + reduced acceptor = AMP + sulfite + acceptor
show the reaction diagram
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Ac-FENAYTAVPSCIASRASILTGMS-NH2 + S-adenosyl-L-methionine + reduced acceptor = Ac-FENAYTAVPS-3-oxo-L-Ala-IASRASILTGMS-NH2 + L-methionine + 5'-deoxyadenosine + acceptor + hydrogen sulfide
show the reaction diagram
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selenate + reduced acceptor = selenite + H2O + acceptor
show the reaction diagram
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a [protein]-S-sulfanyl-L-cysteine + uridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
show the reaction diagram
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a [protein]-S-sulfanyl-L-cysteine + 5-taurinomethyluridine34 in tRNA + ATP + reduced acceptor = a [protein]-L-cysteine + 5-taurinomethyl-2-thiouridine34 in tRNA + AMP + diphosphate + acceptor
show the reaction diagram
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molybdenum cofactor + L-cysteine + reduced acceptor + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O + oxidized acceptor
show the reaction diagram
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L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+
show the reaction diagram
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5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (702 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-sorbitol + acceptor = L-sorbose + reduced acceptor
show the reaction diagram
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glycolate + acceptor = glyoxylate + reduced acceptor
show the reaction diagram
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sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor
show the reaction diagram
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(S)-malate + acceptor = oxaloacetate + reduced acceptor
show the reaction diagram
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ethanol + acceptor = acetaldehyde + reduced acceptor
show the reaction diagram
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(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
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3-hydroxycyclohexanone + acceptor = 1,3-cyclohexanedione + reduced acceptor
show the reaction diagram
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L-sorbose + acceptor = L-sorbosone + reduced acceptor
show the reaction diagram
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(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor
show the reaction diagram
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H2 + acceptor = H+ + reduced acceptor
show the reaction diagram
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