3.4.24.B3: matrix metalloproteinase-11
This is an abbreviated version!
For detailed information about matrix metalloproteinase-11, go to the full flat file.
Word Map on EC 3.4.24.B3
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3.4.24.B3
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metalloproteinases
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metastasis
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mmp-2
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timps
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gelatinase
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microperoxidase-11
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metamorphosis
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tadpole
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matrilysin
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menstrual
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medicine
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stromelysin-2
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microperoxidase
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collagenase-3
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pharmacology
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diagnostics
- 3.4.24.B3
- metalloproteinases
- metastasis
- mmp-2
- timps
- gelatinase
-
microperoxidase-11
-
metamorphosis
- tadpole
- matrilysin
-
menstrual
- medicine
- stromelysin-2
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microperoxidase
- collagenase-3
- pharmacology
- diagnostics
Reaction
proteolytic degradation of proteins =
Synonyms
M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3
ECTree
3.4.24.B3 matrix metalloproteinase-11Advanced search results
results (
results (Engineering
Engineering on EC 3.4.24.B3 - matrix metalloproteinase-11
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A235P
A38V
polymorphismsm rs738792, T/C, may be associated with Kawazaki disease in the Korean population
E216A
E220A
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site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive
P235A
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site-directed mutagenesis, truncated mutant with this introduces point mutation shows reduced enzyme activity against laminin and collgen IV
Q215L
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site-directed mutagenesis, exchange of the residue preceeding the catalytic zinc-binding site results in altered substrate specificity for the P1' position of substrates compared to the wild-type
Q215R
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site-directed mutagenesis, exchange of the residue preceeding the catalytic zinc-binding site results in altered substrate specificity for the P1' position of substrates compared to the wild-type
Q215Y
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site-directed mutagenesis, exchange of the residue preceeding the catalytic zinc-binding site results in altered substrate specificity for the P1' position of substrates compared to the wild-type
additional information
A235P
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mutant shows about 10fold increased activity with alpha1-proteinase inhibitor
A235P
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site-directed mutagenesis, alters substrate specificity, mutant processed and truncated enzyme additionally cleaves casein, laminin, and type IV collagen, Ala 235 is typical for the enzyme and is located immediately after the Met-turn, which forms a catalytic basis for the zinc ion
E216A
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site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive
additional information
recombinant production of a thioredoxin-tagged bioactive recombinant chicken MMP-11 (cMMP-11) peptide excluding the secretory signal and propeptide
additional information
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recombinant production of a thioredoxin-tagged bioactive recombinant chicken MMP-11 (cMMP-11) peptide excluding the secretory signal and propeptide
additional information
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HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, identification of human MHC class I epitopes within human MMP11
additional information
MMP-11 genotyping, identification of single nucleotide polymorphisms
additional information
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MMP-11 genotyping, identification of single nucleotide polymorphisms
additional information
pEnter-MMP-11 plasmid, and MMP-11 small interfering RNA are applied to up- and downregulate MMP-11 expression of in cultured papillary thyroid carcinoma (PTC) cell lines K1 and BCPAP
additional information
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HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, MMP11 vaccine in 1,2-dimethylhydrazine-colon cancer model, overview
additional information
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mice lacking any one particular MMP, including ST3, often show little or weak phenotype
additional information
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MMP-11-/- mice kept on high fat diet show adipocyte hypertrophy in adipose tissues
additional information
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MMP11-deficient mice develop higher numbers of metastases than wild-type mice
additional information
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HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, MMP11 vaccine in 1,2-dimethylhydrazine-colon cancer model, overview
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additional information
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MMP11-deficient mice develop higher numbers of metastases than wild-type mice
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additional information
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transgenic overexpression in tadpoles of ST3 alone is able to induce larval epithelial apoptosis, accompanied by the activation of fibroblasts (i.e. with enriched rough endoplasmic reticulum) just beneath the epithelium and cell-cell contacts between epithelial cells and the fibroblasts. Transgenic overexpression of ST3 preferentially induces apoptosis in the muscles of the tadpole tail, but also in the epidermis, low levels in the connective tissue underlying epidermis
