3.4.24.B3: matrix metalloproteinase-11
This is an abbreviated version!
For detailed information about matrix metalloproteinase-11, go to the full flat file.
Word Map on EC 3.4.24.B3
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3.4.24.B3
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metalloproteinases
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metastasis
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mmp-2
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timps
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gelatinase
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microperoxidase-11
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metamorphosis
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tadpole
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matrilysin
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menstrual
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medicine
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stromelysin-2
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microperoxidase
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collagenase-3
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pharmacology
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diagnostics
- 3.4.24.B3
- metalloproteinases
- metastasis
- mmp-2
- timps
- gelatinase
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microperoxidase-11
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metamorphosis
- tadpole
- matrilysin
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menstrual
- medicine
- stromelysin-2
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microperoxidase
- collagenase-3
- pharmacology
- diagnostics
Reaction
proteolytic degradation of proteins =
Synonyms
M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3
ECTree
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Source Tissue
Source Tissue on EC 3.4.24.B3 - matrix metalloproteinase-11
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increased expression of MMP11 at mRNA and protein levels in cell lines and primary tumors of gastric cancer. Overexpression of MMP11 induced proliferation and invasion in AGS cells
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MMP11 protein is frequently detected in sera of common cancer patients including gastric cancer
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ST-3+/TIMP-2- (stromelysin-3+/matrix metalloproteinase TIMP-2)-phenotype is an adverse prognosticator in esophageal cancer patients
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BGC823. MMP11 may play an important role in the control of cell proliferation and tumor development in gastric cancer
usage of microarray analysis to compare the variations of gene expression within the papillary thyroid carcinoma (PTC) cell populations and their adjacent normal tissues, MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. MMP-11 expression is upregulated in PTC. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation
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expression of stromelysin-3 (matrix metalloproteinase-11) in macrophages of murine thymus following thymocyte apoptosis
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localization to the myotendinous junction (MTJ), laminin is necessary to recruit/retain Mmp11 at the MTJ. Mmp11 is strongly expressed at the MTJ in zebrafish at 2 days post fertilization. Mmp11 expression throughout primary muscle development
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upregulation of stromelysin-3 in the thymus following thymocyte apoptosis
additional information
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cancer cell-adipocyte interaction/crosstalk during the initial steps of cancer cell invasion
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breast tumor tissues display higher expression levels of MMP-11 than the adjacent non-cancerous tissues
samples from patients with histologically confirmed diagnosis of early invasive breast cancers of ductal types, expression of MMP-11 is increased and more heterogeneous in metastatic specimens compared to non-metastatic tumour samples, quantitative expression and mapping of the cancer biomarker MMP-11 in human breast cancer tissue sections, overview
enzyme MMP-11 is expressed exclusively in most primary solid cancer tissues and metastatic lesions
matrix metalloproteinase-11 is observed in most invasive human carcinomas
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expression of wild-type stromelysin-3 leads to extracellular matrix degradation and larval epithelial cell death in the intestine. Stromelysin-3 plays a role in remodeling of extracellular matrix, as a mechanism of T3-induced apoptosis during intestinal metamorphosis
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MMP-11 stimulation in mouse fibroblasts using cytokines, matrix constituents and HBC cell lines
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expression of wild-type stromelysin-3 leads to extracellular matrix degradation and larval epithelial cell death in the intestine. Stromelysin-3 plays a role in remodeling of extracellular matrix, as a mechanism of T3-induced apoptosis during intestinal metamorphosis
immunohistochemistry analysis shows that MMP-11 expression is present in 118/279 (42.3%) cases and expression of MMP-11 is associated with higher incidence of lymph node metastasis and worse grade of tumor differentiation. Cancer distribution, overview
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stromelysin-3 expression, in the absence of thyroid hormone, causes significant muscle cell death in the tail of premetamorphic transgenic tadpoles. On the other hand, only relatively low levels of epidermal cell death are induced by precocious thyroid hormone expression in the tail
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ST3 has little expression in premetamorphic tadpoles, but reaches very high levels by stage 60 when cell death is at high levels in the larval epithelium. It is absent by the end of metamorphosis
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MMP-11 expression analysis in non-malignant gastric tissues and in gastric cancer tissues, immunohistochemic analysis, overview
additional information
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MMP11 is overexpressed in carcinomas compared to healthy tissue
additional information
development and evaluation of a gold nanoparticle-based immunoassay for measuring MMP-11 expression and mapping its distribution pattern in breast cancer tissues, overview
additional information
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development and evaluation of a gold nanoparticle-based immunoassay for measuring MMP-11 expression and mapping its distribution pattern in breast cancer tissues, overview
additional information
overexpression of MMP-11 is reported to be associated with several clinicopathological characteristics, such as poor differentiation, lymph node metastasis and lack of progesterone receptor, in oral squamous cell carcinoma as well as in breast carcinoma. MMP-11 has been initially considered expressed in tumor stroma by fibroblasts surrounding tumor cells instead of by tumor cells themselves
additional information
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overexpression of MMP-11 is reported to be associated with several clinicopathological characteristics, such as poor differentiation, lymph node metastasis and lack of progesterone receptor, in oral squamous cell carcinoma as well as in breast carcinoma. MMP-11 has been initially considered expressed in tumor stroma by fibroblasts surrounding tumor cells instead of by tumor cells themselves
additional information
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MMP-11 expression in benign and malign tissues, detailed overview
additional information
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MMP-11 expression in benign and malign tissues, detailed overview
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additional information
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ST3 expression during amphibian metamorphosis, strong spatiotemporal correlation of its expression with apoptosis in various organs, overview