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Literature summary for 3.4.24.B3 extracted from

  • Zhang, Z.; Dong, T.; Fu, Y.; Zhou, W.; Tian, X.; Chen, G.; Liu, S.
    MMP-11 promotes papillary thyroid cell proliferation and invasion via the NF-kappaB pathway (2019), J. Cell. Biochem., 120, 1860-1868 .
    View publication on PubMed
Search for more literature for 3.4.24.B3

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP11, quantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information pEnter-MMP-11 plasmid, and MMP-11 small interfering RNA are applied to up- and downregulate MMP-11 expression of in cultured papillary thyroid carcinoma (PTC) cell lines K1 and BCPAP Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-
extracellular matrix
-
 Homo sapiens 31012
-
intracellular
-
 Homo sapiens 5622
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc-dependent endopeptidase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P24347
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-CPAP cell
-
 Homo sapiens
-
K1 cell
-
 Homo sapiens
-
papillary thyroid cancer cell usage of microarray analysis to compare the variations of gene expression within the papillary thyroid carcinoma (PTC) cell populations and their adjacent normal tissues, MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. MMP-11 expression is upregulated in PTC. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation Homo sapiens
-

Synonyms

Synonyms Comment Organism
MMP-11
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens MMP-11 expression is upregulated in papillary thyroid carcinoma up

General Information

General Information Comment Organism
malfunction the levels of proliferation and migration of cells transfected with MMP-11 siRNA are significantly reduced, while the levels in MMP-11-plasmid-transfected cells are increased. Variations in intracellular MMP-11 significantly alters the amount of phospho-p65 in thyroid cells, while p65 knockdown does not affect MMP-11 expression Homo sapiens
metabolism MMP-11 regulatory migration is associated with the NF-kappaB p65 signaling pathway Homo sapiens
physiological function matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that digest the intercellular matrix, thereby affecting the tumor microenvironment by promoting angiogenesis, tumor growth, and metastasis. Role of MMP-11 in the mediation of thyroid cancer cell development, as well as in regulation of thyroid cell proliferation and migration. MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation. MMP-11 is located upstream of p65 and regulates its activity. MMP-11 regulatory migration is also associated with the NF-kappaB p65 signaling pathway. MMP-11 promotes activation of p65 Homo sapiens