Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.B3 extracted from

  • Mathew, S.; Fu, L.; Hasebe, T.; Ishizuya-Oka, A.; Shi, Y.B.
    Tissue-dependent induction of apoptosis by matrix metalloproteinase stromelysin-3 during amphibian metamorphosis (2010), Birth Defects Res. C Embryo Today, 90, 55-66.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B3

Protein Variants

Protein Variants Comment Organism
additional information mice lacking any one particular MMP, including ST3, often show little or weak phenotype Mus musculus
additional information transgenic overexpression in tadpoles of ST3 alone is able to induce larval epithelial apoptosis, accompanied by the activation of fibroblasts (i.e. with enriched rough endoplasmic reticulum) just beneath the epithelium and cell-cell contacts between epithelial cells and the fibroblasts. Transgenic overexpression of ST3 preferentially induces apoptosis in the muscles of the tadpole tail, but also in the epidermis, low levels in the connective tissue underlying epidermis Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular matrix
-
 Homo sapiens 31012
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Mus musculus
Zn2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification MMPs with a furin-recognition motif RXKR, such as ST3 and MT-MMPs, are activated intracellularly through a furin-dependent process Mus musculus
proteolytic modification MMPs with a furin-recognition motif RXKR, such as ST3 and MT-MMPs, are activated intracellularly through a furin-dependent process Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
epithelium larval intestinal Xenopus laevis
-
intestine
-
 Xenopus laevis
-
additional information ST3 expression during amphibian metamorphosis, strong spatiotemporal correlation of its expression with apoptosis in various organs, overview Xenopus laevis
-
tadpole ST3 has little expression in premetamorphic tadpoles, but reaches very high levels by stage 60 when cell death is at high levels in the larval epithelium. It is absent by the end of metamorphosis Xenopus laevis
-

Subunits

Subunits Comment Organism
More MMP-11 possesses a furin recognition motif RXKR, but it lacks the C-terminal transmembrane domain of MMPs Mus musculus
More MMP-11 possesses a furin recognition motif RXKR, but it lacks the C-terminal transmembrane domain of MMPs Homo sapiens

Synonyms

Synonyms Comment Organism
MMP11
-
 Mus musculus
MMP11
-
 Homo sapiens
MMP11
-
 Xenopus laevis
More the enzyme belongs to the matrix metalloproteinase superfamily of Zn2+-dependent proteases Mus musculus
More the enzyme belongs to the matrix metalloproteinase superfamily of Zn2+-dependent proteases Homo sapiens
More the enzyme belongs to the matrix metalloproteinase superfamily of Zn2+-dependent proteases Xenopus laevis
ST3
-
 Mus musculus
ST3
-
 Homo sapiens
ST3
-
 Xenopus laevis
stromelysin-3
-
 Mus musculus
stromelysin-3
-
 Homo sapiens
stromelysin-3
-
 Xenopus laevis

Expression

Organism Comment Expression
Xenopus laevis ST3 is thyroid hormone T3-inducible in Xenopus laevis. the mRNA is strongly upregulated by stage 58 in the tadpole intestine, prior to any detectable epithelial apoptosis up

General Information

General Information Comment Organism
physiological function role of MMP11 or stromelysin-3, during the thyroid hormone-dependent amphibian metamorphosis, a process that resembles the so-called postembryonic development in mammals, overview. The metamorphosis requires the removal of unwanted larval cells through programmed cell death, or apoptosis, and proliferation followed by differentiation of adult cell types. Stromelysin-3 controls apoptosis in different tissues via at least two distinct mechanisms, detailed overview Xenopus laevis