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Literature summary for 3.4.24.B3 extracted from
- MMP11: a novel target antigen for cancer immunotherapy (2009), Clin. Cancer Res., 15, 4104-4113.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings | Mus musculus |
| medicine | MMP11 is a novel broadly expressed tumor associated antigen and a target candidate for cancer immunotherapy. Possible use of murine MMP11 as tumor-associated antigen for vaccination of human cancer patients. MMP11 vaccine induces cell-mediated and antibody immune response and exerts significant antitumoral protection in mice with colon cancer in prophylactic and therapeutic settings | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| from NIH-3T3 cells, establishing of a chemically induced, MMP11-overexpressing colon cancer model, overview | Mus musculus |
| MMP11, expression analysis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, identification of human MHC class I epitopes within human MMP11 | Homo sapiens |
| additional information | HLA-A2.1 transgenic mice are used to identify reactive epitopes as tools to assess immunogenicity in humans, MMP11 vaccine in 1,2-dimethylhydrazine-colon cancer model, overview | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Mus musculus |  |
| Zn2+ | dependent on | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
Balb/c mice | - |
| Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | - |
Homo sapiens | - |
| breast cancer cell | - |
Homo sapiens | - |
| carcinoma cell | - |
Mus musculus | - |
| colon | - |
Homo sapiens | - |
| colonic cancer cell | - |
Homo sapiens | - |
| gastric cancer cell | - |
Homo sapiens | - |
| intestine | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| additional information | MMP11 is overexpressed in carcinomas compared to healthy tissue | Homo sapiens | - |
| NIH-3T3 cell | - |
Mus musculus | - |
| renal cancer cell | - |
Homo sapiens | - |
| stomach | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP11 | - |
Mus musculus |
| MMP11 | - |
Homo sapiens |
| stromelysin 3 | - |
Mus musculus |
| stromelysin 3 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | role of MMP11 in cancer progression, MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma | Mus musculus |
| malfunction | role of MMP11 in cancer progression, MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma | Homo sapiens |
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