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2.4.1.222: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

This is an abbreviated version!
For detailed information about O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.222

Reaction

UDP-beta-D-GlcNAc
+
PCQNGGS(O-beta-L-fucosyl)-CKDQL
=
UDP
 +
PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL

Synonyms

acetylglucosaminylferase, uridine diphosphoacetylglucosamine:fucosyglycoprotein beta1-3-, beta-1,3-N-acetyl-glucosaminyltransferase, beta-1,3-N-acetylglucosaminyltransferase, beta1,3-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase, beta1,3-N-acetylglucosaminyltransferase-2, beta1,3-N-acetylglusoaminyltransferase, Dfng, FNG, Fringe, fringe beta1,3 N-acetylglucosaminyltransferase, fringe glycosyltransferase, Fringe O-fucose-beta1,3-N-acetylglucosaminyltransferase, Fringe protein, glycosyltransferase Fringe, LFNG, Lunatic Fringe, lunatic fringe glycosyltransferase, Maniac Fringe, Manic fringe, manic fringe glycosyltransferase, MFng, N-acetylglucosaminyltransferase, O-fucose-beta1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase, O-fucosylpeptide-3-beta-N-acetylglucosaminyltransferase, Radical Fringe, radical fringe glycosyltransferase, Rfng, UDP-acetylglucosamine:fucosylglycoprotein, UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase, UDP-GlcNAc:fucose beta1,3 N-acetylglucosaminyltransferase, UDP-glucose:O-linked fucose beta1,3-glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.222 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Source Tissue

Source Tissue on EC 2.4.1.222 - O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
in the developing brain, Lfng is expressed in self-renewing progenitors
Manually annotated by BRENDA team
manic fringe is highly expressed in claudin-low breast cancer
Manually annotated by BRENDA team
-
expression is relatively constant during germ layer development and occurs in all cells, but becomes restricted during gastrulation
Manually annotated by BRENDA team
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isoform lunatic fringe Lfng is expressed by progenitors in neurogenic regions and downregulated in cells that have initiated neuronal differentiation
Manually annotated by BRENDA team
Lfng is expressed in the distal lung during saccular development
Manually annotated by BRENDA team
Drosophila sp. (in: flies)
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during Drosophila oogenesis
Manually annotated by BRENDA team
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expression levels of three Fringe homologues in naive CD4+T cells in asthmatic rats, overview. Radical Fringe (Rfng) is highly expressed, whereas both Lunatic Fringe (Lfng) and Manic Fringe (Mfng) are expressed at low levels
Manually annotated by BRENDA team
additional information
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distribution, Fringe is expressed in both the signaling and the receiving cells during the first Delta-Notch signal
Manually annotated by BRENDA team