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Literature summary for 2.4.1.222 extracted from

  • Zhang, S.; Chung, W.C.; Wu, G.; Egan, S.E.; Xu, K.
    Tumor-suppressive activity of lunatic fringe in prostate through differential modulation of Notch receptor activation (2014), Neoplasia, 16, 158-167.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene LFNG, quantitative RT-PCR enzyme expression analysis Mus musculus
gene LFNG, quantitative RT-PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of Lfng-/- mice Mus musculus
additional information enzyme knockout by LFNG-small hairpin RNA (shRNA) construct in retroviral red fluorescent protein (RFP) vector targeting 5'-AGCAGGTGACGCTGAGCTACGGTATGTTT- 3' sequences of the human LFNG gene Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch ?
-
?
additional information Mus musculus the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. Lfng inhibits activation of Notch1 and Notch4 in basal cells of the mouse prostate gland while enhancing Notch3 activation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NES3 gene lfng
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Mus musculus O09008 gene lfng
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Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-
epithelial cell
-
Mus musculus
-
epithelial cell
-
Homo sapiens
-
prostate expression of Lfng in the prostate is relatively low compared with manic fringe and radical fringe but more restricted to basal epithelium Mus musculus
-
prostate expression of Lfng in the prostate is relatively low compared with manic fringe and radical fringe but more restricted to basal epithelium Homo sapiens
-
prostate cancer cell
-
Mus musculus
-
prostate cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch Homo sapiens ?
-
?
additional information the enzyme adds N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. Lfng inhibits activation of Notch1 and Notch4 in basal cells of the mouse prostate gland while enhancing Notch3 activation Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
LFNG
-
Mus musculus
LFNG
-
Homo sapiens
Lunatic Fringe
-
Mus musculus
Lunatic Fringe
-
Homo sapiens

General Information

General Information Comment Organism
malfunction deletion of Lfng in mice causes altered Notch activation in the prostate, associated with elevated accumulation of Notch1, Notch2, and Notch4 intracellular domains, decreased levels of the putative Notch3 intracellular fragment, as well as increased expression of Hes1, Hes5, and Hey2. Loss of Lfng results in expansion of the basal layer, increased proliferation of both luminal and basal cells, and ultimately, prostatic intraepithelial neoplasia. The Lfng-null prostate shows down-regulation of prostatic tumor suppressor gene NKX3.1 and increased androgen receptor expression. Deletion of Lfng caused dysregulation of Notch signaling in the prostate. Increased epithelial proliferation and prostatic intraepithelial neoplasia in the Lfng-null mutant gland Mus musculus
malfunction knockdown of LFNG in DU-145 prostate cancer cells leads to expansion of CD44+CD24- and CD49f+CD24- stem/progenitor-like cell population associated with enhanced prostatosphere-forming capacity. The Lfng-null prostate shows down-regulation of prostatic tumor suppressor gene NKX3.1 and increased androgen receptor expression Homo sapiens
additional information expression of LFNG and NKX3.1 are positively correlated in publically available human prostate cancer data sets Homo sapiens
physiological function fringe genes code for O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferases that can add N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. This modification modulates specificity and sensitivity of Notch receptors for different ligands. Therefore, fringes are powerful regulators of ligand-mediated Notch signaling. Tumor-suppressive activity of lunatic fringe in prostate through differential modulation of Notch receptor activation. The enzyme plays a critical role in regulation of prostate epithelial differentiation and proliferation, as well as in prostate tumor suppression Mus musculus
physiological function fringe genes code for O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferases that can add N-acetylglucosamine to O-linked fucose residues on epidermal growth factor repeats of Notch. This modification modulates specificity and sensitivity of Notch receptors for different ligands. Therefore, fringes are powerful regulators of ligand-mediated Notch signaling. Tumor-suppressive activity of lunatic fringe in prostate through differential modulation of Notch receptor activation. The enzyme plays a critical role in regulation of prostate epithelial differentiation and proliferation, as well as in prostate tumor suppression Homo sapiens