Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O09010 | gene lfng | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | Lfng is expressed in the distal lung during saccular development | Mus musculus | - |
myofibroblast | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
LFNG | - |
Mus musculus |
Lunatic Fringe | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of gene lfng impairs myofibroblast differentiation and alveogenesis, alveolar developmental defect in Lfng mutants with altered elastogenesis and collagen deposition in Lfng mutant lungs, phenotype, overview | Mus musculus |
physiological function | Lunatic Fringe, Lfng, is a beta1-3 N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands, Lfng functions to enhance Notch-dependent induction of myofibroblast differentiation during embryonic lung development in the mouse | Mus musculus |