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Literature summary for 2.4.1.222 extracted from

  • Yuan, J.S.; Tan, J.B.; Visan, I.; Matei, I.R.; Urbanellis, P.; Xu, K.; Danska, J.S.; Egan, S.E.; Guidos, C.J.
    Lunatic Fringe prolongs Delta/Notch-induced self-renewal of committed alphabeta T-cell progenitors (2011), Blood, 117, 1184-1195.
    View publication on PubMed
Search for more literature for 2.4.1.222

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
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 Mus musculus 5794
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
spleen
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 Mus musculus
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thymocyte Lfng continues to be highly expressed after thymus-seeding progenitors develop into T cell-committed DN2 (CD117+ CD25+) and then DN3a (CD117- CD25+) pro-T cells, overview Mus musculus
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thymus
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 Mus musculus
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Synonyms

Synonyms Comment Organism
LFNG
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 Mus musculus
Lunatic Fringe
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 Mus musculus

General Information

General Information Comment Organism
malfunction impact of Lfng deficiency on beta-selection, decreasing Lfng expression during the DN3-DP transition minimizes the potent leukemogenic potential of Notch1 signaling Mus musculus
additional information Lfng overexpression enhances proliferative expansion of DN3 and DN4 thymocytes in response to Delta-like ligands in vitro. Lfng overexpression augments binding of Delta-like 1 and Delta-like 4 by double negative and double positive thymocytes Mus musculus
physiological function Fringe proteins are glycosyltransferases that add N-acetylglucosamine to O-fucose moieties to the extracellular domains of Notch receptors. In the immune system, Lunatic Fringe, Lfng, plays a key role in the early stages of T-lymphocyte development, critically enhancing DL4/Notch1-dependent suppression of alternative B-lineage potential and promoting T-lineage specification. Furthermore, Lfng and Manic Fringe cooperatively enhance DL1-induced Notch2 activation to promote marginal zone B-cell development. Lfng enhances Notch1 activation by Delta-like 4 to promote Notch1-dependent T-lineage commitment of thymus-seeding progenitors. Lfng temporally sustains Delta-like-induced Notch1 signaling to prolong proliferative self-renewal of pre-DP thymocytes. Pre-TCR signaling greatly augments Notch trophic functions to promote robust proliferation of pre-double positive progenitors. In the absence of DL/Notch signaling, pre-TCR expressing progenitors rapidly atrophy and differentiate into double positive thymocytes Mus musculus