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Literature summary for 2.4.1.222 extracted from

  • Rampal, R.; Luther, K.B.; Haltiwanger, R.S.
    Notch signaling in normal and disease States: possible therapies related to glycosylation (2007), Curr. Mol. Med., 7, 427-445.
    View publication on PubMed
Search for more literature for 2.4.1.222

Activating Compound

Activating Compound Comment Organism Structure
additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Drosophila melanogaster
additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Mammalia
additional information fringe requires a properly folded EGF repeat modified by O-fucose for its enzymatic activity Homo sapiens

Application

Application Comment Organism
medicine the Notch signaling pathway is involved in numerous developmental cascades in mammals, mutations in the pathway have been implicated in a variety of Human diseases, like CADASIL, spondylocostal dysostosis, alagille syndrome, cancer and multiple sclerosis Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mammalia

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Drosophila melanogaster 5794
-
Golgi apparatus
-
 Mammalia 5794
-
Golgi apparatus
-
 Homo sapiens 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Drosophila melanogaster
Mn2+
-
 Mammalia
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?
additional information Mammalia transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?
additional information Homo sapiens transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mammalia
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mammalia

Source Tissue

Source Tissue Comment Organism Textmining
eye
-
 Drosophila melanogaster
-
leg
-
 Drosophila melanogaster
-
oocyte
-
 Drosophila melanogaster
-
wing
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Drosophila melanogaster ?
-
 ?
additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Mammalia ?
-
 ?
additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,3-N-acetylglucosaminyltransferase
-
 Drosophila melanogaster
beta-1,3-N-acetylglucosaminyltransferase
-
 Mammalia
beta-1,3-N-acetylglucosaminyltransferase
-
 Homo sapiens
Dfng
-
 Drosophila melanogaster