2.1.2.11: 3-methyl-2-oxobutanoate hydroxymethyltransferase

This is an abbreviated version!
For detailed information about 3-methyl-2-oxobutanoate hydroxymethyltransferase, go to the full flat file.

Reaction

Synonyms

5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase, alpha-ketoisovalerate hydroxymethyltransferase, dehydropantoate hydroxymethyltransferase, hydroxymethyltransferase, ketopantoate, ketopantoate hydroxymethyl transferase, ketopantoate hydroxymethyltransferase, KHMT, KPHMT, MOHMT, oxopantoate hydroxymethyltransferase, PanB

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.2 Hydroxymethyl-, formyl- and related transferases

                2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

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Results	in table
38557	AA Sequence
2	Application
1	CAS Registry Number
10	Cloned(Commentary)
30	Cofactor
2	Crystallization (Commentary)
10	General Information
2	General Stability
17	Inhibitors
22	KM Value [mM]
4	Localization
21	Metals/Ions
19	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
58	Organism
7	Pathway
45	PDB ID
7	pH Optimum
3	pH Range
4	pH Stability
1	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
10	Reaction
1	Reaction Type
24	Reference
13	Specific Activity [micromol/min/mg]
1	Storage Stability
61	Substrates and Products (Substrate)
7	Subunits
26	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Stability [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.2.11 - 3-methyl-2-oxobutanoate hydroxymethyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

19 entries

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O

tetrahydrofolate + 2-dehydropantoate

4 entries

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Aspergillus nidulans

Q9Y7B6

essential for the biosynthesis of coenzyme A

485708

-

485708

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Bacillus subtilis

-

biosynthesis of pantothenate

485705

-

485705

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first committed step in pantothenate biosynthesis

485700

-

485700

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first committed step in pantothenate biosynthesis

485701

-

485701

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first committed step in pantothenate biosynthesis

485704

-

485704

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first committed step in pantothenate biosynthesis

485707

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first committed step in pantothenate biosynthesis

485699

enzyme is responsible for catalysis of ketopantoate formation in vivo

485699

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

catalytic activity is regulated by the products of the reaction path of which it is one component

485700

-

485700

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

biosynthesis of coenzyme A

485702

-

485702

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

biosynthesis of coenzyme A

485704

-

485704

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

first step in pantoate biosynthesis

485703

-

485703

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Mycobacterium tuberculosis

-

first committed step in pantothenate biosynthesis

485706

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Mycobacterium tuberculosis

-

first committed step in pantothenate biosynthesis

485710

-

485710

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Mycobacterium tuberculosis

-

enzyme may be the rate-limiting reaction in pantothenate biosynthesis

485710

-

485710

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Mycobacterium tuberculosis KIT 10468

-

first committed step in pantothenate biosynthesis

485706

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Mycobacterium tuberculosis variant bovis

-

first committed step in pantothenate biosynthesis

485706

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Salmonella enterica

-

biosynthesis of pantothenate

485709

-

485709

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Salmonella enterica

-

enzyme may be the rate-limiting reaction in pantothenate biosynthesis

485709

-

485709

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate

tetrahydrofolate + 2-dehydropantoate

Salmonella enterica subsp. enterica serovar Typhimurium

-

first committed step in pantothenate biosynthesis

485699

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O

tetrahydrofolate + 2-dehydropantoate

Corynebacterium glutamicum

-

-

756758

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O

tetrahydrofolate + 2-dehydropantoate

Corynebacterium glutamicum ATCC 13032

-

-

756758

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O

tetrahydrofolate + 2-dehydropantoate

Escherichia coli

-

-

756787

-

-

?

5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O

tetrahydrofolate + 2-dehydropantoate

Escherichia coli W3110

-

-

756787

-

-

?