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Literature summary for 2.1.2.11 extracted from

  • Aberhart, D.J.
    Stereochemistry of pantoate biosynthesis from 2-ketoisovalerate (1979), J. Am. Chem. Soc., 101, 1354-1355.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate Escherichia coli first step in pantoate biosynthesis tetrahydrofolate + 2-dehydropantoate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
strain ATCC 23783
-

Reaction

Reaction Comment Organism Reaction ID
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate stereochemistry Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate inversion of the configuration at C-3 of 2-ketoisovalerate Escherichia coli tetrahydrofolate + 2-dehydropantoate
-
?
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate first step in pantoate biosynthesis Escherichia coli tetrahydrofolate + 2-dehydropantoate
-
?

Cofactor

Cofactor Comment Organism Structure
5,10-methylenetetrahydrofolate
-
Escherichia coli
tetrahydrofolate
-
Escherichia coli