Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain BW25113 or MG1655 | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O | Escherichia coli | - |
tetrahydrofolate + 2-dehydropantoate | - |
? | |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O | Escherichia coli W3110 | - |
tetrahydrofolate + 2-dehydropantoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli W3110 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O | - |
Escherichia coli | tetrahydrofolate + 2-dehydropantoate | - |
? | |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate + H2O | - |
Escherichia coli W3110 | tetrahydrofolate + 2-dehydropantoate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ketopantoate hydroxymethyltransferase | - |
Escherichia coli |
PanB | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,10-methenyltetrahydrofolate | dependent on | Escherichia coli |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme overexpression leads to accumulation of the likely folate cleavage product 6-hydroxymethylpterin and other pterins in cells and medium, and to a 46% increase in total folate content | Escherichia coli |