Cloned (Comment) | Organism |
---|---|
panB gene encoding enzyme is clustered together with other pantothenate biosynthetic genes panC and panD at 3 min of the chromosome map, panBCD operon | Salmonella enterica |
Protein Variants | Comment | Organism |
---|---|---|
additional information | panBp654 mutant with insertion of one GC base pair upstream of the transcription start site results in an optimized panBCD promoter and a 10fold increase in transcription of the pan operon, i.e. an increased expression of panB, which is sufficient to increase pantothenate biosynthesis | Salmonella enterica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | Salmonella enterica | biosynthesis of pantothenate | tetrahydrofolate + 2-dehydropantoate | - |
? | |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | Salmonella enterica | enzyme may be the rate-limiting reaction in pantothenate biosynthesis | tetrahydrofolate + 2-dehydropantoate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | - |
serovar typhimurium | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | - |
Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? | |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | biosynthesis of pantothenate | Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? | |
5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate | enzyme may be the rate-limiting reaction in pantothenate biosynthesis | Salmonella enterica | tetrahydrofolate + 2-dehydropantoate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,10-methylenetetrahydrofolate | - |
Salmonella enterica | |
tetrahydrofolate | - |
Salmonella enterica |