Reference on EC 4.6.1.1 - adenylate cyclase and Organism(s) Homo sapiens and UniProt Accession O43306
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Read, L.K.; Mikkelsen, R.B.
Plasmodium falciparum-infected erythrocytes contain an adenylate cyclase with properties which differ from those of the host enzyme
Mol. Biochem. Parasitol.
45
109-120
1991
Homo sapiens, Plasmodium falciparum
Reddy, N.B.; Oliver, K.L.; Festoff, B.W.; Engel, W.K.
Adenylate cyclase system of human skeletal muscle subcellular distribution and general problems
Biochim. Biophys. Acta
540
371-388
1978
Homo sapiens
-
Wedner, H.J.; Parker, C.W.
Adenylate cyclase activity in lymphocyte subcellular fractions. Characterization of a nuclear adenylate cyclase
Biochem. J.
162
483-491
1977
Homo sapiens
Hellevuo, K.; Yoshimura, M.; Mons, N.; Hoffman, P.L.; Cooper, D.M.F.; Tabakoff, B.
The characterization of a novel human adenylyl cyclase which is present in brain and other tissues
J. Biol. Chem.
270
11581-11589
1995
Homo sapiens
Khan, N.A.; Quemener, V.; Moulinoux, J.P.
Inhibition of adenylate cyclase activity by polyamines in human erythrocyte plasma membranes
Life Sci.
46
43-47
1990
Homo sapiens
Wadman, I.A.; Farndale, R.W.; Martin, B.R.
Evidence for regulation of human platelet adenylate cyclase by phosphorylation. Inhibition by ATP and guanosine 5 -[beta-thio]diphosphate occur by distinct mechanisms
Biochem. J.
276
621-630
1991
Homo sapiens
Hanoune, J.; Defer, N.
Regulation and role of adenylyl cyclase isoforms
Annu. Rev. Pharmacol. Toxicol.
41
145-174
2001
Homo sapiens
McVey, M.; Hill, J.; Howlett, A.; Klein, C.
Adenylyl cyclase, a coincidence detector for nitric oxide
J. Biol. Chem.
274
18887-18892
1999
Homo sapiens
Litvin, T.N.; Kamenetsky, M.; Zarifyan, A.; Buck, J.; Levin, L.R.
Kinetic Properties of "Soluble" Adenylyl Cyclase. Synergism between calcium and bicarbonate
J. Biol. Chem.
278
15922-15926
2003
Homo sapiens
Cumbay, M.G.; Watts, V.J.
Novel Regulatory Properties of Human Type 9 Adenylate Cyclase (AC9)
J. Pharmacol. Exp. Ther.
310
108-115
2004
Homo sapiens
Rhee, M.H.; Nevo, I.; Avidor-Reiss, T.; Levy, R.; Vogel, Z.
Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB1 cannabinoid receptor
Mol. Pharmacol.
57
746-752
2000
Homo sapiens
Bernatchez, R.; Belkacemi, L.; Rassart, E.; Daoud, G.; Simoneau, L.; Lafond, J.
Differential expression of membrane and soluble adenylyl cyclase isoforms in cytotrophoblast cells and syncytiotrophoblasts of human placenta
Placenta
24
648-657
2003
Homo sapiens, Homo sapiens (O43306), Homo sapiens (O60266), Homo sapiens (O95622), Homo sapiens (P40145), Homo sapiens (P51828), Homo sapiens (Q08462), Homo sapiens (Q08828), Homo sapiens (Q96PN6)
Asboth, G.; Price, S.A.; Bellinger, J.; Ledger, W.; Barlow, D.H.; Bernal, A.L.
Characterization of adenylyl cyclases in cultured human granulosa cells
Reproduction
121
217-228
2001
Homo sapiens
Jaleel, M.; Shenoy, A.R.; Visweswariah, S.S.
Tyrphostins Are Inhibitors of Guanylyl and Adenylyl Cyclases
Biochemistry
43
8247-8255
2004
Homo sapiens
Chen-Goodspeed, M.; Lukan, A.N.; Dessauer, C.W.
Modeling of Gas and Gai Regulation of Human Type V and VI Adenylyl Cyclase
J. Biol. Chem.
280
1808-1816
2005
Homo sapiens
Steegborn, C.; Litvin, T.N.; Hess, K.C.; Capper, A.B.; Taussig, R.; Buck, J.; Levin, L.R.; Wu, H.
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
J. Biol. Chem.
280
31754-31759
2005
Homo sapiens, Arthrospira platensis
Yoshimura, M.; Pearson, S.; Kadota, Y.; Gonzalez, C.E.
Identification of ethanol responsive domains of adenylyl cyclase
Alcohol. Clin. Exp. Res.
30
1824-1832
2006
Rattus norvegicus (P21932), Rattus norvegicus (P26769), Homo sapiens (P51828)
Kolachala, V.L.; Obertone, T.S.; Wang, L.; Merlin, D.; Sitaraman, S.V.
Adenosine 2b receptor (A2bR) signals through adenylate cyclase (AC) 6 isoform in the intestinal epithelial cells
Biochim. Biophys. Acta
1760
1102-1108
2006
Cricetulus griseus, Homo sapiens
Baudouin-Legros, M.; Hamdaoui, N.; Borot, F.; Fritsch, J.; Ollero, M.; Planelles, G.; Edelman, A.
Control of Basal CFTR Gene Expression by Bicarbonate-Sensitive Adenylyl Cyclase in Human Pulmonary Cells
Cell. Physiol. Biochem.
21
75-86
2008
Homo sapiens
Beazely, M.A.; Watts, V.J.
Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Eur. J. Pharmacol.
535
1-12
2006
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Nlend, M.C.; Schmid, A.; Sutto, Z.; Ransford, G.A.; Conner, G.E.; Fregien, N.; Salathe, M.
Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia
FEBS Lett.
581
3241-3246
2007
Homo sapiens
Gao, X.; Sadana, R.; Dessauer, C.W.; Patel, T.B.
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits
J. Biol. Chem.
282
294-302
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Willoughby, D.; Cooper, D.M.
Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP
J. Cell Sci.
119
828-836
2006
Homo sapiens
Schmid, A.; Sutto, Z.; Nlend, M.C.; Horvath, G.; Schmid, N.; Buck, J.; Levin, L.R.; Conner, G.E.; Fregien, N.; Salathe, M.
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP
J. Gen. Physiol.
130
99-109
2007
Homo sapiens
Antoni, F.A.; Wiegand, U.K.; Black, J.; Simpson, J.
Cellular localisation of adenylyl cyclase: a post-genome perspective
Neurochem. Res.
31
287-295
2006
Homo sapiens, Macaca sp., Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Willoughby, D.; Cooper, D.M.
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
Physiol. Rev.
87
965-1010
2007
Aplysia sp., Canis lupus familiaris, Oryctolagus cuniculus, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Paramecium sp., Rattus norvegicus, Tetrahymena sp., Plasmodium sp.
Cooper, D.M.; Crossthwaite, A.J.
Higher-order organization and regulation of adenylyl cyclases
Trends Pharmacol. Sci.
27
426-431
2006
Homo sapiens
Koukoulitsa, C.; Zervou, M.; Demetzos, C.; Mavromoustakos, T.
Comparative docking studies of labdane-type diterpenes with forskolin at the active site of adenylyl cyclase
Bioorg. Med. Chem.
16
8237-8243
2008
Homo sapiens
Eyler, C.E.; Jackson, T.; Elliott, L.E.; De Castro, L.M.; Jonassaint, J.; Ashley-Koch, A.; Telen, M.J.
beta2-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion
Br. J. Haematol.
141
105-108
2008
Homo sapiens
Wann, B.P.; DAnjou, B.; Bah, T.M.; Webster, H.H.; Godbout, R.; Rousseau, G.
Effect of olfactory bulbectomy on adenylyl cyclase activity in the limbic system
Brain Res. Bull.
79
32-36
2009
Homo sapiens, Rattus norvegicus
Ichikawa, S.; Koller, D.L.; Curry, L.R.; Lai, D.; Xuei, X.; Edenberg, H.J.; Hui, S.L.; Peacock, M.; Foroud, T.; Econs, M.J.
Association of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults
Calcif. Tissue Int.
84
97-102
2009
Homo sapiens
Kloster, M.M.; Hafte, T.T.; Moltzau, L.R.; Naderi, E.H.; Dahle, M.K.; Skalhegg, B.S.; Gaudernack, G.; Levy, F.O.; Naderi, S.; Blomhoff, H.K.
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell. Signal.
20
1169-1178
2008
Homo sapiens
Thangavel, M.; Liu, X.; Sun, S.Q.; Kaminsky, J.; Ostrom, R.S.
The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae
Cell. Signal.
21
301-308
2009
Homo sapiens
Jiang, L.I.; Collins, J.; Davis, R.; Fraser, I.D.; Sternweis, P.C.
Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII
J. Biol. Chem.
283
23429-23439
2008
Homo sapiens (P51828), Homo sapiens (P51829)
Sakihama, T.; Masuda, K.; Sato, T.; Doi, T.; Kodama, T.; Hamakubo, T.
Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system
J. Biotechnol.
135
28-33
2008
Homo sapiens (O43306)
Tovey, S.C.; Dedos, S.G.; Taylor, E.J.; Church, J.E.; Taylor, C.W.
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP
J. Cell Biol.
183
297-311
2008
Homo sapiens (O43306), Homo sapiens (O60266), Homo sapiens
Schlicker, C.; Rauch, A.; Hess, K.C.; Kachholz, B.; Levin, L.R.; Buck, J.; Steegborn, C.
Structure-based development of novel adenylyl cyclase inhibitors
J. Med. Chem.
51
4456-4464
2008
Rattus norvegicus, Arthrospira platensis (O32393), Homo sapiens (Q96PN6), Homo sapiens
Donati, R.J.; Dwivedi, Y.; Roberts, R.C.; Conley, R.R.; Pandey, G.N.; Rasenick, M.M.
Postmortem brain tissue of depressed suicides reveals increased Gs alpha localization in lipid raft domains where it is less likely to activate adenylyl cyclase
J. Neurosci.
28
3042-3050
2008
Homo sapiens
Brown, J.T.; Kant, A.; Mailman, R.B.
Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: Application in GPCR-mediated adenylate cyclase assays
J. Neurosci. Methods
177
261-266
2009
Homo sapiens
Clark, M.J.; Linderman, J.J.; Traynor, J.R.
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model
Mol. Pharmacol.
73
1538-1548
2008
Homo sapiens
Dwivedi, Y.; Pandey, G.N.
Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
Neuropsychiatr. Disease Treat.
4
161-176
2008
Homo sapiens
Ryzhov, S.; Zaynagetdinov, R.; Goldstein, A.E.; Matafonov, A.; Biaggioni, I.; Feoktistov, I.
Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8
Purinergic Signal.
5
289-298
2009
Cricetulus griseus, Homo sapiens
Rhim, J.H.; Jang, I.S.; Song, K.Y.; Ha, M.K.; Cho, S.C.; Yeo, E.J.; Park, S.C.
Lysophosphatidic acid and adenylyl cyclase inhibitor increase proliferation of senescent human diploid fibroblasts by inhibiting adenosine monophosphate-activated protein kinase
Rejuvenation Res.
11
781-792
2008
Homo sapiens
Koshimizu, T.A.; Tsuchiya, H.; Tsuda, H.; Fujiwara, Y.; Shibata, K.; Hirasawa, A.; Tsujimoto, G.; Fujimura, A.
Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment
Biochem. Biophys. Res. Commun.
392
603-607
2010
Homo sapiens
Mou, T.C.; Masada, N.; Cooper, D.M.; Sprang, S.R.
Structural basis for inhibition of mammalian adenylyl cyclase by calcium
Biochemistry
48
3387-3397
2009
Homo sapiens
Oener, S.S.; Kaya, A.I.; Onaran, H.O.; Oezcan, G.; Ugur, O.
beta2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions
Eur. J. Pharmacol.
630
42-52
2010
Homo sapiens
Macdougall, D.A.; Wachten, S.; Ciruela, A.; Sinz, A.; Cooper, D.M.
Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart Ca2+/calmodulin binding and autoinhibition
J. Biol. Chem.
284
15573-15588
2009
Homo sapiens
Suryanarayana, S.; Goettle, M.; Huebner, M.; Gille, A.; Mou, T.C.; Sprang, S.R.; Richter, M.; Seifert, R.
Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2,3-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5-triphosphates
J. Pharmacol. Exp. Ther.
330
687-695
2009
Homo sapiens
Werthmann, R.C.; von Hayn, K.; Nikolaev, V.O.; Lohse, M.J.; Buenemann, M.
Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6
J. Physiol.
587
4091-4104
2009
Homo sapiens
Taylor, M.; Grundt, P.; Griffin, S.A.; Newman, A.H.; Luedtke, R.R.
Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways
Synapse
64
251-266
2010
Homo sapiens
Hasanuzzaman, M.; Yoshimura, M.
Effects of straight chain alcohols on specific isoforms of adenylyl cyclase
Alcohol. Clin. Exp. Res.
34
743-749
2010
Homo sapiens
Pinto, C.; Lushington, G.H.; Richter, M.; Gille, A.; Geduhn, J.; Koenig, B.; Mou, T.C.; Sprang, S.R.; Seifert, R.
Structure-activity relationships for the interactions of 2'- and 3'-(O)-(N-methyl)anthraniloyl-substituted purine and pyrimidine nucleotides with mammalian adenylyl cyclases
Biochem. Pharmacol.
82
358-370
2011
Homo sapiens
Kleinboelting, S.; Diaz, A.; Moniot, S.; van den Heuvel, J.; Weyand, M.; Levin, L.R.; Buck, J.; Steegborn, C.
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Proc. Natl. Acad. Sci. USA
111
3727-3732
2014
Homo sapiens
Kleinboelting, S.; Ramos-Espiritu, L.; Buck, H.; Colis, L.; van den Heuvel, J.; Glickman, J.F.; Levin, L.R.; Buck, J.; Steegborn, C.
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site
J. Biol. Chem.
291
9776-9784
2016
Homo sapiens (Q96PN6), Homo sapiens
