Reference on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamaguchi, H.; Kajitani, K.; Dan, Y.; Furuichi, M.; Ohno, M.; Sakumi, K.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Cell Death Differ.
13
551-563
2006
Homo sapiens (P36639), Mus musculus (P53368)
Kajitani, K.; Yamaguchi, H.; Dan, Y.; Furuichi, M.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity
J. Neurosci.
26
1688-1698
2006
Mus musculus
Cai, J.P.; Ishibashi, T.; Takagi, Y.; Hayakawa, H.; Sekiguchi, M.
Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides
Biochem. Biophys. Res. Commun.
305
1073-1077
2003
Mus musculus (Q8BG93)
Bialkowski, K.; Kasprzak, K.S.
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate
Free Radic. Biol. Med.
37
1534-1541
2004
Homo sapiens, Mus musculus
Hori, M.; Satou, K.; Harashima, H.; Kamiya, H.
Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5
Free Radic. Biol. Med.
48
1197-1201
2010
Homo sapiens (P36639)
Sakumi, K.; Furuichi, M.; Tsuzuki, T.; Kakuma, T.; Kawabata, S.; Maki, H.; Sekiguchi, M.
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
J. Biol. Chem.
268
23524-23530
1993
Homo sapiens (P36639)
Kakuma, T.; Nishida, J.; Tsuzuki, T.;, Sekiguchi, M.
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution
J. Biol. Chem.
270
25942-25948
1995
Mus musculus (P53368)
Fujikawa, K.; Kamiya, H.; Yakushiji, H.; Fujii, Y.; Nakabeppu, Y.; Kasai, H.
The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein
J. Biol. Chem.
274
18201-18205
1999
Homo sapiens
Sakai, Y.; Furuichi, M.; Takahashi, M.; Mishima, M.; Iwai, S.; Shirakawa, M.; Nakabeppu, Y.
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1
J. Biol. Chem.
277
8579-8587
2002
Homo sapiens (P36639)
Mishima, M.; Sakai, Y.; Itoh, N.; Kamiya, H.; Furuichi, M.; Takahashi, M.; Yamagata, Y.; Iwai, S.; Nakabeppu, Y.; Shirakawa, M.
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
J. Biol. Chem.
279
33806-33815
2004
Homo sapiens (P36639)
Takahashi, M.; Maraboeuf, F.; Sakai, Y.; Yakushiji, H.; Mishima, M.; Shirakawa, M.; Iwai, S.; Hayakawa, H.; Sekiguchi, M.; Nakabeppu, Y.
Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein
J. Mol. Biol.
319
129-139
2002
Homo sapiens (P36639)
Yakushiji, H.; Maraboeuf, F.; Takahashi, M.; Deng, Z.S.; Kawabata, S.; Nakabeppu, Y.; Sekiguchi, M.
Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity
Mutat. Res.
384
181-194
1997
Homo sapiens
Nakabeppu, Y.; Oka, S.; Sheng, Z.; Tsuchimoto, D.; Sakumi, K.
Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase
Mutat. Res.
703
51-58
2010
Homo sapiens, Mus musculus
Song, X.N.; Zhang, L.Q.; Liu, D.G.; Lin, J.; Zheng, J.D.; Dai, D.P.; Hei, A.L.; Hayakawa, H.; Sekiguchi, M.; Cai, J.P.
Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients
Neurochem. Res.
36
1558-1565
2011
Homo sapiens, Mus musculus, Mus musculus SAMP8
Fujikawa, K.; Kamiya, H.; Yakushiji, H.; Nakabeppu, Y.; Kasai, H.
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP
Nucleic Acids Res.
29
449-454
2011
Homo sapiens
Ishibashi, T.; Hayakawa, H.; Ito, R.; Miyazawa, M.; Yamagata, Y.; Sekiguchi, M.
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage
Nucleic Acids Res.
33
3779-3784
2005
Homo sapiens
Bialkowski, K.; Szpila, A.; Kasprzak, K.S.
Up-regulation of 8-oxo-dGTPase activity of MTH1 protein in the brain, testes and kidneys of mice exposed to (137)Cs gamma radiation
Radiat. Res.
172
187-197
2009
Mus musculus
Narwal, M.; Jemth, A.S.; Gustafsson, R.; Almloef, I.; Warpman Berglund, U.; Helleday, T.; Stenmark, P.
Crystal structures and inhibitor interactions of mouse and dog MTH1 reveal species-specific differences in affinity
Biochemistry
57
593-603
2018
Canis lupus familiaris (F1P963), Homo sapiens (P36639), Mus musculus (P53368)
Kumar, A.; Kawamura, T.; Kawatani, M.; Osada, H.; Zhang, K.
Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors
Chem. Biol. Drug Des.
89
862-869
2017
Homo sapiens (P36639)
Waz, S.; Nakamura, T.; Hirata, K.; Koga-Ogawa, Y.; Chirifu, M.; Arimori, T.; Tamada, T.; Ikemizu, S.; Nakabeppu, Y.; Yamagata, Y.
Structural and kinetic studies of the human Nudix hydrolase MTH1 reveal the mechanism for its broad substrate specificity
J. Biol. Chem.
292
2785-2794
2017
Homo sapiens
Kimura, Y.; Kajimoto, S.; Yamamoto, Y.; Tanaka, N.
Enzymatic characteristics of Nudix hydrolase 2 (Nud2), an 8-oxo-dGTP hydrolase from Myxococcus xanthus
J. Gen. Appl. Microbiol.
66
46-50
2020
Myxococcus xanthus
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