Literature summary for 3.6.1.56 extracted from

Yamaguchi, H.; Kajitani, K.; Dan, Y.; Furuichi, M.; Ohno, M.; Sakumi, K.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2006), Cell Death Differ., 13, 551-563.

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Protein Variants

Protein Variants	Comment	Organism
D119A	mutant enzyme shows no hydrolytic activity with 2-hydroxy-dATP. Specific activity with 8-oco-dGTP is 139% of wild-type activity	Homo sapiens
W117Y	mutant enzyme shows hydrolytic acitivity with 8-oxo-dGTP. Specific activity with 2-hydroxy-dATP is 86% of wild-type activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-hydroxy-dATP + H2O	Homo sapiens	MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction	2-hydroxy-dAMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P36639	-	-
Mus musculus	P53368	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-hydroxy-dATP + H2O	-	Homo sapiens	2-hydroxy-dAMP + diphosphate	-	?
2-hydroxy-dATP + H2O	MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP. These alterations may be partly attributed to a mitochondrial dysfunction	Homo sapiens	2-hydroxy-dAMP + diphosphate	-	?
8-oxo-dGTP + H2O	this enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP	Homo sapiens	8-oxo-dGMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
MTH1	-	Mus musculus
MTH1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	MTH1 protects the dopamine neurons from oxidative damage in the nucleic acids, especially in the mitochondrial DNA of striatal nerve terminals of dopamine neurons	Mus musculus

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Release 2023.1 (January 2023)