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Literature summary for 3.6.1.56 extracted from

  • Nakabeppu, Y.; Oka, S.; Sheng, Z.; Tsuchimoto, D.; Sakumi, K.
    Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase (2010), Mutat. Res., 703, 51-58.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
2-hydroxy-dATP pH and temperature not specified in the publication Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Mus musculus 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate 8-oxo-dGMP + diphosphate
-
?
8-oxo-dGTP + H2O Homo sapiens 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP 8-oxo-dGMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction Mus musculus
-
brain oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction Homo sapiens
-
embryonic fibroblast
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxy-ATP + H2O
-
Mus musculus 2-hydroxy-AMP + diphosphate
-
?
2-hydroxy-ATP + H2O
-
Homo sapiens 2-hydroxy-AMP + diphosphate
-
?
2-hydroxy-dATP + H2O
-
Mus musculus 2-hydroxy-dAMP + diphosphate
-
?
2-hydroxy-dATP + H2O
-
Homo sapiens 2-hydroxy-dAMP + diphosphate
-
?
8-oxo-ATP + H2O
-
Mus musculus 8-oxo-AMP + diphosphate
-
?
8-oxo-ATP + H2O
-
Homo sapiens 8-oxo-AMP + diphosphate
-
?
8-oxo-dATP + H2O
-
Mus musculus 8-oxo-dAMP + diphosphate
-
?
8-oxo-dATP + H2O
-
Homo sapiens 8-oxo-dAMP + diphosphate
-
?
8-oxo-dGTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate Mus musculus 8-oxo-dGMP + diphosphate
-
?
8-oxo-dGTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP Homo sapiens 8-oxo-dGMP + diphosphate
-
?
8-oxo-GTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate Mus musculus 8-oxo-GMP + diphosphate
-
?
8-oxo-GTP + H2O 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate Homo sapiens 8-oxo-GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
MTH1
-
Mus musculus
MTH1
-
Homo sapiens

Expression

Organism Comment Expression
Mus musculus oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction up
Homo sapiens oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction up

General Information

General Information Comment Organism
malfunction MTH1-null mouse embryo fibroblasts are highly susceptible to cell dysfunction and death caused by exposure to H2O2, with condensed nuclei and degenerated mitochondria in which electron dense deposits are seen in place of intact cristae. The cell death observed is not dependent on either poly(ADP-ribose) polymerase or caspases. A continuous accumulation of 8-oxoG, both in the nuclear and mitochondrial DNA, is observed after exposure to H2O2. All of the H2O2-induced alterations observed in MTH1-null MEFs are effectively suppressed by the expression of wild-type human MTH1 Mus musculus
physiological function MTH1, a major sanitizing enzyme for oxidized nucleotide pools plays a crucial role by suppressing their accumulation in cellular DNA. In addition to oxidized purine deoxyribonucleoside triphosphates, MTH1 efficiently hydrolyzes oxidized purine ribonucleoside triphosphates such as 2-hydroxy-ATP, 8-oxo-ATP and, to a lesser extent, 8-oxo-GTP Mus musculus
physiological function MTH1, a major sanitizing enzyme for oxidized nucleotide pools plays a crucial role by suppressing their accumulation in cellular DNA. In addition to oxidized purine deoxyribonucleoside triphosphates, MTH1 efficiently hydrolyzes oxidized purine ribonucleoside triphosphates such as 2-hydroxy-ATP, 8-oxo-ATP and, to a lesser extent, 8-oxo-GTP Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.00168
-
2-hydroxy-dATP pH and temperature not specified in the publication Homo sapiens