KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0043 | - |
2-hydroxy-dATP | pH and temperature not specified in the publication | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
8-oxo-dGTP + H2O | Mus musculus | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | 8-oxo-dGMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | Homo sapiens | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | 8-oxo-dGMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction | Mus musculus | - |
brain | oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction | Homo sapiens | - |
embryonic fibroblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxy-ATP + H2O | - |
Mus musculus | 2-hydroxy-AMP + diphosphate | - |
? | |
2-hydroxy-ATP + H2O | - |
Homo sapiens | 2-hydroxy-AMP + diphosphate | - |
? | |
2-hydroxy-dATP + H2O | - |
Mus musculus | 2-hydroxy-dAMP + diphosphate | - |
? | |
2-hydroxy-dATP + H2O | - |
Homo sapiens | 2-hydroxy-dAMP + diphosphate | - |
? | |
8-oxo-ATP + H2O | - |
Mus musculus | 8-oxo-AMP + diphosphate | - |
? | |
8-oxo-ATP + H2O | - |
Homo sapiens | 8-oxo-AMP + diphosphate | - |
? | |
8-oxo-dATP + H2O | - |
Mus musculus | 8-oxo-dAMP + diphosphate | - |
? | |
8-oxo-dATP + H2O | - |
Homo sapiens | 8-oxo-dAMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | Mus musculus | 8-oxo-dGMP + diphosphate | - |
? | |
8-oxo-dGTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP | Homo sapiens | 8-oxo-dGMP + diphosphate | - |
? | |
8-oxo-GTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | Mus musculus | 8-oxo-GMP + diphosphate | - |
? | |
8-oxo-GTP + H2O | 8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | Homo sapiens | 8-oxo-GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MTH1 | - |
Mus musculus |
MTH1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction | up |
Homo sapiens | oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction | up |
General Information | Comment | Organism |
---|---|---|
malfunction | MTH1-null mouse embryo fibroblasts are highly susceptible to cell dysfunction and death caused by exposure to H2O2, with condensed nuclei and degenerated mitochondria in which electron dense deposits are seen in place of intact cristae. The cell death observed is not dependent on either poly(ADP-ribose) polymerase or caspases. A continuous accumulation of 8-oxoG, both in the nuclear and mitochondrial DNA, is observed after exposure to H2O2. All of the H2O2-induced alterations observed in MTH1-null MEFs are effectively suppressed by the expression of wild-type human MTH1 | Mus musculus |
physiological function | MTH1, a major sanitizing enzyme for oxidized nucleotide pools plays a crucial role by suppressing their accumulation in cellular DNA. In addition to oxidized purine deoxyribonucleoside triphosphates, MTH1 efficiently hydrolyzes oxidized purine ribonucleoside triphosphates such as 2-hydroxy-ATP, 8-oxo-ATP and, to a lesser extent, 8-oxo-GTP | Mus musculus |
physiological function | MTH1, a major sanitizing enzyme for oxidized nucleotide pools plays a crucial role by suppressing their accumulation in cellular DNA. In addition to oxidized purine deoxyribonucleoside triphosphates, MTH1 efficiently hydrolyzes oxidized purine ribonucleoside triphosphates such as 2-hydroxy-ATP, 8-oxo-ATP and, to a lesser extent, 8-oxo-GTP | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00168 | - |
2-hydroxy-dATP | pH and temperature not specified in the publication | Homo sapiens |