Reference on EC 3.4.21.35 - tissue kallikrein and Organism(s) Homo sapiens and UniProt Accession Q9UBX7
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P06870), Macaca fascicularis (Q07276), Mastomys natalensis (P32824), Mus musculus (P00755), Papio hamadryas (Q28773), Rattus norvegicus (P00758)
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens, Homo sapiens (P06870)
El Moujahed, A.; Brillard-Bourdet, M.; Juliano, M.A.; Moreau, T.; Chagas, J.R.; Gutman, N.; Prado, E.S.; Gauthier, F.
Kininogen-derived fluorogenic substrates for investigating the vasoactive properties of rat kallikreins. Identification of a T-kinin-releasing rat kallikrein
Eur. J. Biochem.
247
652-658
1997
Homo sapiens, Rattus norvegicus
Hofmann, W.; Junk, A.; Geiger, R.
Human tissue kallikrein. II. Isolation and characterization of human salivary kallikrein
Hoppe-Seyler's Z. Physiol. Chem.
364
425-432
1983
Homo sapiens
Webster, M.E.; Prado, E.S.
Glandular kallikreins from horse and human urine and from hog pancreas
Methods Enzymol.
19
681-699
1970
Equus caballus, Homo sapiens, Sus scrofa
-
Geiger, R.; Clausnitzer, B.; Fink, H.; Fritz, H.
Isolation of an enzymatically active glandular kallikrein from human plasma by immunoaffinity chromatography
Hoppe-Seyler's Z. Physiol. Chem.
361
179-1803
1980
Homo sapiens
-
Takada, Y.; Skidgel, R.A.; Erds, E.G.
Purification of human urinary prokallikrein
Biochem. J.
232
851-858
1985
Homo sapiens
Geiger, R.; Clausnitzer, B.
Isolation of an enzymatically active tissue kallikrein from human seminal plasma by immunoaffinity chromatography
Hoppe-Seyler's Z. Physiol. Chem.
362
1279-1283
1981
Homo sapiens
Pimenta, D.C.; Fogaca, S.E.; Melo, R.L.; Juliano, L.; Juliano, M.A.
Specificity of S'1 and S'2 subsites of human tissue kallikrein using the reactive-centre loop of kallistatin: the importance of P'1 and P'2 positions in design of inhibitors
Biochem. J.
371
1021-1025
2003
Homo sapiens
Girolami, J.P.; Pecher, C.; Bascands, J.L.; Cabos, G.; Adam, A.; Suc, J.M.
Purification of human active urinary kallikrein: comparative inhibition studies of kininogenase and amidolytic activities
Prep. Biochem.
19
175-190
1989
Homo sapiens
-
Chan, H.; Springman, E.B.; Clark, J.M.
Expression and characterization of human tissue kallikrein variants
Protein Expr. Purif.
12
361-370
1998
Homo sapiens
Fujimoto, Y.; Suzuki, C.; Watanabe, Y.; Matsuda, Y.; Akihama, S.
Purification and characterization of a kallikrein from human submaxillary glands
Biochem. Med. Metab. Biol.
44
218-227
1990
Homo sapiens
Lu, H.S.; Hsu, Y.R.; Narhi, L.O.; Karkare, S.; Lin, F.K.
Purification and characterization of human tissue prokallikrein and kallikrein isoforms expressed in Chinese hamster ovary cells
Protein Expr. Purif.
8
227-237
1996
Homo sapiens
Lu, H.S.; Hsu, Y.R.; Lu, L.I.; Ruff, D.; Lyons, D.; Lin, F.K.
Isolation and characterization of human tissue kallikrein produced in Escherichia coli: biochemical comparison to the enzymatically inactive prokallikrein and methionyl kallikrein
Protein Expr. Purif.
8
215-226
1996
Homo sapiens
Geiger, R.; Miska, W.
Human tissue kallikrein
Methods Enzymol.
163
102-115
1988
Homo sapiens
Jones, T.H.; Figueroa, C.D.; Smith, C.; Cullen, D.R.; Bhoola, K.D.
Characterization of a tissue kallikrein in human prolactin-secreting aenomas
J. Endocrinol.
124
327-331
1990
Homo sapiens
Oliva, M.L.; Mendes, C.R.; Juliano, M.A.; Chagas, J.R.; Rosa, J.C.; Greene, L.J.; Sampaio, M.U.; Sampaio, C.A.
Characterization of a tissue kallikrein inhibitor isolated from Bauhinia bauhinioides seeds: inhibition of the hydrolysis of kininogen related substrates
Immunopharmacology
45
163-169
1999
Homo sapiens, Sus scrofa
Del Nery, E.; Chagas, J.R.; Juliano, M.A.; Juliano, L.; Prado, E.S.
Comparison of human and porcine tissue kallikrein substrate specificities
Immunopharmacology
45
151-157
1999
Homo sapiens, Sus scrofa
Pimenta, D.C.; Chao, J.; Chao, L.; Juliano, M.A.; Juliano, L.
Specificity of human tissue kallikrein towards substrates containing Phe-Phe pair of amino acids
Biochem. J.
339
473-479
1999
Homo sapiens
Chen, V.C.; Chao, L.; Chao, J.
Roles of the P1, P2, and P3 residues in determining inhibitory specificity of kallistatin toward human tissue kallikrein
J. Biol. Chem.
275
38457-38466
2000
Homo sapiens
Chen, V.C.; Chao, L.; Chao, J.
A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein
J. Biol. Chem.
275
40371-40377
2000
Homo sapiens
Melo, R.L.; Barbosa Pozzo, R.C.; Pimenta, D.C.; Perissutti, E.; Caliendo, G.; Santagada, V.; Juliano, L.; Juliano, M.A.
Human tissue kallikrein S1 subsite recognition of non-natural basic amino acids
Biochemistry
40
5226-5232
2001
Homo sapiens
Clements, J.; Hooper, J.; Dong, Y.; Harvey, T.
The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
Biol. Chem.
382
5-14
2001
Homo sapiens (P06870)
Sakamoto, W.; Yoshikawa, K.; Uehara, S.; Nishikaze, O.
Characterization of human salivary kallikrein: reactivities to human plasma kininogens and proteinase inhibitors
J. Biochem.
93
833-838
1983
Homo sapiens
Katz, B.A.; Liu, B.; Barnes, M.; Springman, E.B.
Crystal structure of recombinant human tissue kallikrein at 2.0 A resolution
Protein Sci.
7
875-885
1998
Homo sapiens
Lvgren, J.; Airas, K.; Lilja, H.
Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors
Eur. J. Biochem.
262
781-789
1999
Homo sapiens
Charlesworth, M.C.; Young, C.Y.; Miller, V.M.; Tindall, D.J.
Kininogenase activity of prostate-derived human glandular kallikrein (hK2) purified from seminal fluid
J. Androl.
20
220-229
1999
Homo sapiens
Saedi, M.S.; Zhu, Z.; Marker, K.; Liu, R.S.; Carpenter, P.M.; Rittenhouse, H.; Mikolajczyk, S.D.
Human kallikrein 2 (hK2), but not prostate-specific antigen (PSA), rapidly complexes with protease inhibitor 6 (PI-6) released from prostate carcinoma cells
Int. J. Cancer
94
558-563
2001
Homo sapiens
Rehault, S.; Monget, P.; Mazerbourg, S.; Tremblay, R.; Gutman, N.; Gauthier, F.; Moreau, T.
Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3
Eur. J. Biochem.
268
2960-2968
2001
Homo sapiens
Yousef, G.M.; Diamandis, E.P.
Expanded human tissue kallikrein family-a novel panel of cancer biomarkers
Tumour Biol.
23
185-192
2002
Homo sapiens
Cloutier, S.M.; Chagas, J.R.; Mach, J.P.; Gygi, C.M.; Leisinger, H.J.; Deperthes, D.
Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology
Eur. J. Biochem.
269
2747-2754
2002
Homo sapiens
Beaufort, N.; Debela, M.; Creutzburg, S.; Kellermann, J.; Bode, W.; Schmitt, M.; Pidard, D.; Magdolen, V.
Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
Biol. Chem.
387
217-222
2006
Homo sapiens
Olsson, A.Y.; Bjartell, A.; Lilja, H.; Lundwall, A.
Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissues
Int. J. Cancer
113
290-297
2005
Homo sapiens
Fogaca, S.E.; Melo, R.L.; Pimenta, D.C.; Hosoi, K.; Juliano, L.; Juliano, M.A.
Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
Biochem. J.
380
775-781
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Memari, N.; Grass, L.; Nakamura, T.; Karakucuk, I.; Diamandis, E.P.
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
Biol. Chem.
387
733-740
2006
Homo sapiens
Rosatelli, T.B.; Roselino, A.M.; Dellalibera-Joviliano, R.; Reis, M.L.; Donadi, E.A.
Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem)
Br. J. Dermatol.
152
650-657
2005
Homo sapiens
Luo, L.Y.; Shan, S.J.; Elliott, M.B.; Soosaipillai, A.; Diamandis, E.P.
Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma
Clin. Cancer Res.
12
742-750
2006
Homo sapiens (Q9UBX7)
Cloutier, S.M.; Kuendig, C.; Felber, L.M.; Fattah, O.M.; Chagas, J.R.; Gygi, C.M.; Jichlinski, P.; Leisinger, H.J.; Deperthes, D.
Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
Eur. J. Biochem.
271
607-613
2004
Homo sapiens
Steuber, T.; Vickers, A.J.; Haese, A.; Becker, C.; Pettersson, K.; Chun, F.K.; Kattan, M.W.; Eastham, J.A.; Scardino, P.T.; Huland, H.; Lilja, H.
Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum
Int. J. Cancer
118
1234-1240
2006
Homo sapiens
Casalino-Matsuda, S.M.; Monzon, M.E.; Conner, G.E.; Salathe, M.; Forteza, R.M.
Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways
J. Biol. Chem.
279
21606-21616
2004
Homo sapiens
Azizi, M.; Boutouyrie, P.; Bissery, A.; Agharazii, M.; Verbeke, F.; Stern, N.; Bura-Riviere, A.; Laurent, S.; Alhenc-Gelas, F.; Jeunemaitre, X.
Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans
J. Clin. Invest.
115
780-787
2005
Homo sapiens
De Sousa, M.O.; Santoro, M.M.; De Souza Figueiredo, A.F.
The effect of cations on the amidase activity of human tissue kallikrein: 1-linear competitive inhibition by sodium, potassium, calcium and magnesium. 2-linear mixed inhibition by aluminium
J. Enzyme Inhib. Med. Chem.
19
317-325
2004
Homo sapiens
Komatsu, N.; Tsai, B.; Sidiropoulos, M.; Saijoh, K.; Levesque, M.A.; Takehara, K.; Diamandis, E.P.
Quantification of eight tissue kallikreins in the Stratum corneum and sweat
J. Invest. Dermatol.
126
925-929
2006
Homo sapiens
Borgono, C.A.; Michael, I.P.; Diamandis, E.P.
Human tissue kallikreins: physiologic roles and applications in cancer
Mol. Cancer Res.
2
257-280
2004
Homo sapiens
Gao, B.; Sun, H.C.; Fang, H.X.; Qian, K.; Zhao, M.S.; Qiu, H.L.; Song, C.Y.; Wang, Z.Y.
Expression and preliminary characterization of recombinant human tissue kallikrein in egg white of laying hens
Poult. Sci.
85
1239-1244
2006
Homo sapiens
Sharma, J.N.
Role of tissue kallikrein-kininogen-kinin pathways in the cardiovascular system
Arch. Med. Res.
37
299-306
2006
Homo sapiens
Pampalakis, G.; Sotiropoulou, G.
Tissue kallikrein proteolytic cascade pathways in normal physiology and cancer
Biochim. Biophys. Acta
1776
22-31
2007
Homo sapiens
Paliouras, M.; Diamandis, E.P.
The kallikrein world: an update on the human tissue kallikreins
Biol. Chem.
387
643-652
2006
Homo sapiens
Chao, J.; Bledsoe, G.; Yin, H.; Chao, L.
The tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction
Biol. Chem.
387
665-675
2006
Homo sapiens
Paliouras, M.; Borgono, C.; Diamandis, E.P.
Human tissue kallikreins: the cancer biomarker family
Cancer Lett.
249
61-79
2007
Homo sapiens
Li, H.J.; Yin, H.; Yao, Y.Y.; Shen, B.; Bader, M.; Chao, L.; Chao, J.
Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation
Cardiovasc. Res.
73
130-142
2007
Homo sapiens
Yuan, G.; Deng, J.; Wang, T.; Zhao, C.; Xu, X.; Wang, P.; Voltz, J.W.; Edin, M.L.; Xiao, X.; Chao, L.; Chao, J.; Zhang, X.A.; Zeldin, D.C.; Wang, D.W.
Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of phosphatidylinositol 3-kinase/protein kinase B and adenosine 5-monophosphate-activated protein kinase signaling pathways
Endocrinology
148
2016-2026
2007
Homo sapiens
Scarisbrick, I.A.; Blaber, S.I.; Tingling, J.T.; Rodriguez, M.; Blaber, M.; Christophi, G.P.
Potential scope of action of tissue kallikreins in CNS immune-mediated disease
J. Neuroimmunol.
178
167-176
2006
Homo sapiens (P06870)
Naidoo, S.; Raidoo, D.M.
Tissue kallikrein and kinin receptor expression in an angiogenic co-culture neuroblastoma model
Metab. Brain Dis.
21
253-265
2006
Homo sapiens
Madeddu, P.; Emanueli, C.; El-Dahr, S.
Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling
Nat. Clin. Pract. Nephrol.
3
208-221
2007
Homo sapiens
Stone, O.A.; Richer, C.; Emanueli, C.; van Weel, V.; Quax, P.H.; Katare, R.; Kraenkel, N.; Campagnolo, P.; Barcelos, L.S.; Siragusa, M.; Sala-Newby, G.B.; Baldessari, D.; Mione, M.; Vincent, M.P.; Benest, A.V.; Al Haj Zen, A.; Gonzalez, J.; Bates, D.O.; Alhenc-Gelas, F.; Madeddu, P.
Critical role of tissue kallikrein in vessel formation and maturation. Implications for therapeutic revascularization
Arterioscler. Thromb. Vasc. Biol.
29
657-664
2009
Homo sapiens
Weber, W.; Buck, F.; Meyer, A.; Hilz, H.
Prostate specific antigen: one out of five disulfide bridges determines inactivation by reduction
Biochem. Biophys. Res. Commun.
379
1101-1106
2009
Homo sapiens
Clements, J.A.
Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
Biol. Chem.
389
1447-1454
2008
Homo sapiens, Mus musculus
Lima, A.R.; Alves, F.M.; Angelo, P.F.; Andrade, D.; Blaber, S.I.; Blaber, M.; Juliano, L.; Juliano, M.A.
S(1) and S(2) subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen
Biol. Chem.
389
1487-1494
2008
Homo sapiens
Eissa, A.; Diamandis, E.P.
Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions
Biol. Chem.
389
669-680
2008
Homo sapiens
Pizard, A.; Richer, C.; Bouby, N.; Picard, N.; Meneton, P.; Azizi, M.; Alhenc-Gelas, F.
Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney
Biol. Chem.
389
701-706
2008
Homo sapiens
Yao, Y.Y.; Yin, H.; Shen, B.; Smith, R.S.; Liu, Y.; Gao, L.; Chao, L.; Chao, J.
Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway
Cardiovasc. Res.
80
354-364
2008
Homo sapiens
Prassas, I.; Paliouras, M.; Datti, A.; Diamandis, E.P.
High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies
Clin. Cancer Res.
14
5778-5784
2008
Homo sapiens
Tu, L.; Xu, X.; Wan, H.; Zhou, C.; Deng, J.; Xu, G.; Xiao, X.; Chen, Y.; Edin, M.L.; Voltz, J.W.; Zeldin, D.C.; Wang, D.W.
Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats
Hum. Gene Ther.
19
318-330
2008
Homo sapiens
Christiansen, S.C.; Eddleston, J.; Bengtson, S.H.; Jenkins, G.R.; Sarnoff, R.B.; Turner, R.B.; Gwaltney, J.M.; Zuraw, B.L.
Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects
Int. Arch. Allergy Immunol.
147
299-304
2008
Homo sapiens
Silva, J.A.; Silva, M.R.; Nascimento, J.W.; Bader, M.; Pesquero, J.B.
Protective actions of human tissue kallikrein gene in transgenic rat hearts
Int. Immunopharmacol.
8
267-270
2008
Homo sapiens
Wenske, S.; Korets, R.; Cronin, A.M.; Vickers, A.J.; Fleisher, M.; Scher, H.I.; Pettersson, K.; Guillonneau, B.; Scardino, P.T.; Eastham, J.A.; Lilja, H.
Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy
Int. J. Cancer
124
659-663
2009
Homo sapiens
Azizi, M.; Emanueli, C.; Peyrard, S.; Maddedu, P.; Alhenc-Gelas, F.; Campbell, D.J.
Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins exretion in man
J. Hypertens.
26
714-720
2008
Homo sapiens
Chiang, W.C.; Lin, S.L.; Chen, Y.M.; Wu, K.D.; Tsai, T.J.
Urinary kallikrein excretion is related to renal function change and inflammatory status in chronic kidney disease patients receiving angiotensin II receptor blocker treatment
Nephrology
13
198-203
2008
Homo sapiens
Wang, A.P.; Sun, H.C.; Wang, J.Y.; Wang, Y.J.; Yuan, W.F.
Recombinant avian adeno-associated virus-mediated oviduct-specific expression of recombinant human tissue kallikrein
Poult. Sci.
87
777-782
2008
Homo sapiens
Yan, J.T.; Wang, T.; Wang, D.W.
Recombinant adeno-associated virus-mediated human kallikrein gene therapy protects against hypertensive target organ injuries through inhibiting cell apoptosis
Acta Pharmacol. Sin.
30
1253-1261
2009
Homo sapiens
Sexton, D.J.; Chen, T.; Martik, D.; Kuzmic, P.; Kuang, G.; Chen, J.; Nixon, A.E.; Zuraw, B.L.; Forteza, R.M.; Abraham, W.M.; Wood, C.R.
Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases
Biochem. J.
422
383-392
2009
Ovis aries, Homo sapiens, Mus musculus
Chao, J.; Shen, B.; Gao, L.; Xia, C.F.; Bledsoe, G.; Chao, L.
Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing
Biol. Chem.
391
345-355
2010
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Gao, L.; Smith, R.S.; Chen, L.M.; Chai, K.X.; Chao, L.; Chao, J.
Tissue kallikrein promotes prostate cancer cell migration and invasion via protease-activated receptor-1-dependent signaling pathway
Biol. Chem.
391
803-812
2010
Homo sapiens, Rattus norvegicus
Liu, L.; Zhang, R.; Liu, K.; Zhou, H.; Yang, X.; Liu, X.; Tang, M.; Su, J.; Dong, Q.
Tissue kallikrein protects cortical neurons against in vitro ischemia-acidosis/reperfusion-induced injury through the ERK1/2 pathway
Exp. Neurol.
219
453-465
2009
Homo sapiens
Chen, Z.B.; Huang, D.Q.; Niu, F.N.; Zhang, X.; Li, E.G.; Xu, Y.
Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappaB
J. Cereb. Blood Flow Metab.
30
1356-1365
2010
Homo sapiens
Liu, L.; Zhang, R.; Liu, K.; Zhou, H.; Tang, Y.; Su, J.; Yu, X.; Yang, X.; Tang, M.; Dong, Q.
Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1
J. Neurosci. Res.
87
3576-3590
2009
Homo sapiens
Tang, S.C.; Chan, L.Y.; Leung, J.C.; Cheng, A.S.; Chan, K.W.; Lan, H.Y.; Lai, K.N.
Bradykinin and high glucose promote renal tubular inflammation
Nephrol. Dial. Transplant.
25
698-710
2010
Homo sapiens
Naidoo, S.; Raidoo, D.M.
Angiogenesis in cervical cancer is mediated by HeLa metabolites through endothelial cell tissue kallikrein
Oncol. Rep.
22
285-293
2009
Homo sapiens
Zhang, Q.; Ding, H.; Yan, J.; Wang, W.; Ma, A.; Zhu, Z.; Cianflone, K.; Hu, F.B.; Hui, R.; Wang, D.W.
Plasma tissue kallikrein level is negatively associated with incident and recurrent stroke: a multicenter case-control study in China
Ann. Neurol.
70
265-273
2011
Homo sapiens
Nakamura, S.; Morimoto, N.; Tsuruma, K.; Izuta, H.; Yasuda, Y.; Kato, N.; Ikeda, T.; Shimazawa, M.; Hara, H.
Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165
Arterioscler. Thromb. Vasc. Biol.
31
1041-1048
2011
Homo sapiens
Dominek, P.; Campagnolo, P.; H-Zadeh, M.; Kraenkel, N.; Chilosi, M.; Sharman, J.A.; Caporali, A.; Mangialardi, G.; Spinetti, G.; Emanueli, C.; Pignatelli, M.; Madeddu, P.
Role of human tissue kallikrein in gastrointestinal stromal tumour invasion
Br. J. Cancer
103
1422-1431
2010
Homo sapiens
Spinetti, G.; Fortunato, O.; Cordella, D.; Portararo, P.; Kraenkel, N.; Katare, R.; Sala-Newby, G.B.; Richer, C.; Vincent, M.P.; Alhenc-Gelas, F.; Tonolo, G.; Cherchi, S.; Emanueli, C.; Madeddu, P.
Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells
Circ. Res.
108
284-293
2011
Homo sapiens
Wang, Y.D.; Lu, R.Y.; Huang, X.X.; Yuan, F.; Hu, T.; Peng, Y.; Huang, S.Q.
Human tissue kallikrein promoted activation of the ipsilesional sensorimotor cortex after acute cerebral infarction
Eur. Neurol.
65
208-214
2011
Homo sapiens
Lu, Z.; Yang, Q.; Cui, M.; Liu, Y.; Wang, T.; Zhao, H.; Dong, Q.
Tissue kallikrein induces SH-SY5Y cell proliferation via epidermal growth factor receptor and extracellular signal-regulated kinase1/2 pathway
Biochem. Biophys. Res. Commun.
446
25-29
2014
Homo sapiens
Oliveira, J.R.; Bertolin, T.C.; Andrade, D.; Oliveira, L.C.; Kondo, M.Y.; Santos, J.A.; Blaber, M.; Juliano, L.; Severino, B.; Caliendo, G.; Santagada, V.; Juliano, M.A.
Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity
Biochim. Biophys. Acta
1854
73-83
2015
Homo sapiens
Su, J.; Tang, Y.; Zhou, H.; Liu, L.; Dong, Q.
Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c
Cell. Signal.
24
2205-2215
2012
Homo sapiens
Yao, Y.Y.; Fu, C.; Ma, G.S.; Feng, Y.; Shen, C.X.; Wu, G.Q.; Zhang, X.G.; Ding, J.D.; Tang, C.C.; Chen, Z.; Dai, Q.M.; Tong, J.Y.; Luo, D.; Zhu, J.; Zhi, H.; Li, Y.J.; Ju, C.W.; Lu, J.; Chao, J.; Chao, L.
Tissue kallikrein is related to the severity of coronary artery disease
Clin. Chim. Acta
423
90-98
2013
Homo sapiens
Yao, Y.; Sheng, Z.; Li, Y.; Yan, F.; Fu, C.; Li, Y.; Ma, G.; Liu, N.; Chao, J.; Chao, L.
Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity
Hum. Gene Ther.
23
859-870
2012
Homo sapiens
Koumandou, V.L.; Scorilas, A.
Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms
PLoS ONE
8
e68074
2013
Homo sapiens
Yiu, W.H.; Wong, D.W.; Chan, L.Y.; Leung, J.C.; Chan, K.W.; Lan, H.Y.; Lai, K.N.; Tang, S.C.
Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells
PLoS One
9
e88894
2014
Homo sapiens
Pathak, M.; Wong, S.S.; Dreveny, I.; Emsley, J.
Structure of plasma and tissue kallikreins
Thromb. Haemost.
110
423-433
2013
Homo sapiens, Homo sapiens (P06870)
Petraki, C.; Youssef, Y.M.; Dubinski, W.; Lichner, Z.; Scorilas, A.; Pasic, M.D.; Komborozos, V.; Khalil, B.; Streutker, C.; Diamandis, E.P.; Yousef, G.M.
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer
Tumour Biol.
33
1209-1214
2012
Homo sapiens
Figueroa, C.D.; Molina, L.; Bhoola, K.D.; Ehrenfeld, P.
Overview of tissue kallikrein and kallikrein-related peptidases in breast cancer
Biol. Chem.
399
937-957
2018
Homo sapiens
Santos, J.A.; Kondo, M.Y.; Freitas, R.F.; dos Santos, M.H.; Ramalho, T.C.; Assis, D.M.; Juliano, L.; Juliano, M.A.; Puzer, L.
The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
Bioorg. Med. Chem. Lett.
26
1485-1489
2016
Homo sapiens
Filippou, P.S.; Ren, A.H.; Bala, S.; Papaioannou, M.D.; Brinc, D.; Prassas, I.; Karakosta, T.; Diamandis, E.P.
Biochemical characterization of human tissue kallikrein 15 and examination of its potential role in cancer
Clin. Biochem.
58
108-115
2018
Homo sapiens (Q9H2R5), Homo sapiens
Liu, Y.; Lu, Z.; Cui, M.; Yang, Q.; Tang, Y.; Dong, Q.
Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose deprivation-induced injury through bradykinin B2 receptor-dependent regulation of autophagy induction
J. Neurochem.
139
208-220
2016
Homo sapiens
Chen, J.; Wu, J.; Wu, Q.; Hu, Z.
Biosynthesis and secretion of human tissue kallikrein in transgenic Chlamydomonas reinhardtii
Mar. Drugs
16
E493
2018
Homo sapiens
