Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | KLKs are secreted as pro-KLK zymogens upon removal of their pre-peptide signal, cleavage of the pro-peptide induces a conformational change in the active site and substrate pocket, resulting in extracellular activation of the mature enzyme | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | tissue kallikreins, particularly KLK6, are considered potential candidates for epithelial antimetastatic therapy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | granular keratinocyte | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
KLK | - |
Homo sapiens |