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Literature summary for 3.4.21.35 extracted from
- Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions (2008), Biol. Chem., 389, 669-680.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | KLKs are secreted as pro-KLK zymogens upon removal of their pre-peptide signal, cleavage of the pro-peptide induces a conformational change in the active site and substrate pocket, resulting in extracellular activation of the mature enzyme | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | tissue kallikreins, particularly KLK6, are considered potential candidates for epithelial antimetastatic therapy | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | granular keratinocyte | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KLK | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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