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Literature summary for 3.4.21.35 extracted from
- Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappaB (2010), J. Cereb. Blood Flow Metab., 30, 1356-1365.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| urine | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HUK | - |
Homo sapiens |
| urinary kallidinogenase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | HUK reduces brain damage in experimental stroke: in a mouse middle cerebral artery occlusion model, HUK significantly improves neurofunction, decreases infarct size, and suppresses edema, as well as inflammatory mediators as compared with the vehicle group. Furthermore, HUK inhibits the NF-kappaB pathway and activates the MAPK/ERK pathway in this neuroprotection | Homo sapiens |
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Release 2023.1 (January 2023)
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