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2-oxoimidazolidinyl-4-carbonyl-Gly-Ile + H2O
?
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
5-pyrrolidone-2-carboxyl-His-Gly + H2O
?
-
slight activity
-
-
?
5-pyrrolidone-2-carboxyl-His-Trp + H2O
?
-
-
-
-
?
ACE inhibitor + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Trp-
-
?
acid-thyroliberin + H2O
pyroglutamate + His-Pro
bombesin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Arg-
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
bradykinin potentiator + H2O
pyroglutamate + ?
bradykinin potentiator B + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Gly-
-
?
bradykinin-potentiating peptide B + H2O
?
-
cleavage of the peptide bond adjacent to the pyroglutamic residue
-
-
?
ethyl L-pyroglutamate + H2O
L-pyroglutamate + ethanol
Fibrinogen + H2O
?
-
bovine fribrinogen
-
-
?
Glu(OMe)2-litorin + H2O
pyroglutamate + ?
-
-
-
?
gonadotropin-releasing hormone + H2O
?
hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate + H2O
?
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-ethanolamine + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
L-pyroglutamic acid 2-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
-
?
L-pyroglutamyl p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
-
?
L-pyroglutamyl-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
?
L-pyroglutamyl-aminoethylnitrate + H2O
?
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphtylamine
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphtylamine
-
-
-
-
?
L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O
L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
L-pyroglutamyl-L-Ile + H2O
L-pyroglutamate + L-Ile
-
-
-
-
?
L-pyroglutamyl-L-Thr + H2O
L-pyroglutamate + L-Thr
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutaminic acid + p-nitroaniline
-
-
-
?
L-pyrrolidonyl 2-naphthylamide + H2O
5-oxo-L-proline + 2-naphthylamine
-
-
-
-
?
leukopyrokinin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Thr-
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
luteinizing hormone releasing hormone + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-His-
-
?
luteinizing-hormone-releasing hormone + H2O
?
N-(4-methyl-2-oxo-2H-chromen-7-yl)-5-oxo-L-prolinamide + H2O
5-oxo-L-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
neurotensin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Leu-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
pyroglutamic acid-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-2-naphthylamide + H2O
pyroglutamate + 2-naphthylamine
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
pyroglutamyl-4-methylcoumaryl-7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
?
pyroglutamyl-4-methylumbelliferyl ester + H2O
?
-
-
-
-
?
pyroglutamyl-Ala + H2O
pyroglutamate + Ala
pyroglutamyl-Arg + H2O
pyroglutamate + Arg
-
-
-
-
?
pyroglutamyl-Asp + H2O
pyroglutamate + Asp
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
pyroglutamyl-D-Ala + H2O
pyroglutamate + D-Ala
pyroglutamyl-D-Leu + H2O
pyroglutamate + D-Leu
-
-
-
-
?
pyroglutamyl-Glu + H2O
pyroglutamate + Glu
-
-
-
-
?
pyroglutamyl-Gly + H2O
pyroglutamate + Gly
-
-
-
-
?
pyroglutamyl-Gly-Ile + H2O
pyroglutamate + Gly-Ile
-
-
-
-
?
pyroglutamyl-His + H2O
pyroglutamate + His
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
pyroglutamyl-His-Gly-NH2 + H2O
pyroglutamate + His-Gly-NH2
pyroglutamyl-His-Pro-Gly + H2O
pyroglutamate + His-Pro-Gly
-
-
-
-
?
pyroglutamyl-His-Pro-Gly-NH2 + H2O
pyroglutamate + His-Pro-Gly-NH2
-
-
-
-
?
pyroglutamyl-Ile + H2O
pyroglutamate + Ile
-
-
-
-
?
pyroglutamyl-Leu + H2O
pyroglutamate + Leu
-
-
-
-
?
pyroglutamyl-Lys + H2O
pyroglutamate + Lys
-
-
-
-
?
pyroglutamyl-Met + H2O
pyroglutamate + Met
-
-
-
-
?
pyroglutamyl-p-nitroanilide + H2O
pyroglutamate + p-nitroaniline
pyroglutamyl-peptide + H2O
pyroglutamate + peptide
-
the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases
-
?
pyroglutamyl-Phe + H2O
pyroglutamate + Phe
-
-
-
-
?
pyroglutamyl-Phe-Pro-NH2 + H2O
pyroglutamate + Phe-Pro-NH2
-
-
-
-
?
pyroglutamyl-Ser + H2O
pyroglutamate + Ser
-
-
-
-
?
pyroglutamyl-Thr + H2O
pyroglutamate + Thr
-
-
-
-
?
pyroglutamyl-Trp + H2O
pyroglutamate + Trp
-
-
-
-
?
pyroglutamyl-Tyr + H2O
pyroglutamate + Tyr
-
-
-
-
?
pyroglutamyl-Val + H2O
pyroglutamate + Val
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
thyroliberin-releasing hormone + H2O
?
-
-
-
-
?
thyrotrophin releasing hormone
?
thyrotrophin-releasing hormone + H2O
?
thyrotropin-releasing hormone + H2O
?
additional information
?
-
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
acid-thyroliberin + H2O
pyroglutamate + His-Pro
-
-
-
-
?
acid-thyroliberin + H2O
pyroglutamate + His-Pro
-
i.e. pyroglutamyl-His-Pro
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
-
-
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
i.e. pyroglutamyl-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
?
bradykinin potentiator + H2O
pyroglutamate + ?
-
-
-
-
?
bradykinin potentiator + H2O
pyroglutamate + ?
-
-
-
?
ethyl L-pyroglutamate + H2O
L-pyroglutamate + ethanol
-
-
-
?
ethyl L-pyroglutamate + H2O
L-pyroglutamate + ethanol
-
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
-
frog litorin
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
-
frog litorin
-
?
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
i.e. pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
?
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
-
-
-
?
luteinizing-hormone-releasing hormone + H2O
?
-
-
-
-
?
luteinizing-hormone-releasing hormone + H2O
?
-
-
-
-
?
luteinizing-hormone-releasing hormone + H2O
?
-
-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
i.e. pyroglutamyl-Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
-
-
-
?
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
-
-
-
?
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-Ala + H2O
pyroglutamate + Ala
-
-
-
-
?
pyroglutamyl-Ala + H2O
pyroglutamate + Ala
-
-
-
-
?
pyroglutamyl-Ala + H2O
pyroglutamate + Ala
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus aureus
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus aureus ATCC 25923
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus pseudintermedius
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus pseudintermedius LMG 22219T
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-D-Ala + H2O
pyroglutamate + D-Ala
-
-
-
-
?
pyroglutamyl-D-Ala + H2O
pyroglutamate + D-Ala
-
slight activity
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
-
i.e. anorexogenic peptide
-
?
pyroglutamyl-His-Gly-NH2 + H2O
pyroglutamate + His-Gly-NH2
-
-
-
-
?
pyroglutamyl-His-Gly-NH2 + H2O
pyroglutamate + His-Gly-NH2
-
-
-
-
?
pyroglutamyl-p-nitroanilide + H2O
pyroglutamate + p-nitroaniline
-
-
-
-
?
pyroglutamyl-p-nitroanilide + H2O
pyroglutamate + p-nitroaniline
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
removes the N-terminal pyroglutamic acid
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
i.e. pyroglutamyl-His-Pro-NH2, i.e. thyrotrophin releasing hormone
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
-
-
-
?
thyrotrophin releasing hormone
?
-
the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space
-
-
?
thyrotrophin releasing hormone
?
-
-
-
-
?
thyrotrophin-releasing hormone + H2O
?
trypanosomal pyroglutamyl aminopeptidase I is responsible for the abnormally rapid degradation of thyrotrophin-releasing hormone in the circulation of infected rats
-
-
?
thyrotrophin-releasing hormone + H2O
?
hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond
-
-
?
thyrotropin-releasing hormone + H2O
?
-
-
-
?
thyrotropin-releasing hormone + H2O
?
-
-
-
?
thyrotropin-releasing hormone + H2O
?
-
-
-
-
?
thyrotropin-releasing hormone + H2O
?
-
-
-
?
additional information
?
-
-
slight activity toward L-pyroglutamyl-D-amino acids, inert toward L-pyroglutamyl-L-Pro
-
-
?
additional information
?
-
-
the molecular recognition of pyroglutamic acid is achieved through two hydrogen bonds and an insertion in the hydrophobic pocket. In the pocket Phe10 is more important to the hydrophobic interaction than is Phe142 and furthermore Phe13 serves as an induced fit mechanism
-
?
additional information
?
-
-
the enzyme does not catalyze the hydrolysis of peptides with six-membered ureido rings at the amino terminus, but it tolerates well a five-membered ureido ring at this position
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
no hydrolysis of dipeptides containing N-terminal pyroglutamic acid or with pyroglutamyl peptides containing more than three amino acids
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
the enzyme is inactive towards uperolein and piperidone carbonyl His-Pro-NH2
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
enzyme may participate in regulating the levels of seminal thyrotropin-relasing hormone analogues and in mediating sperm death associated with necrozoospermia
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
pyroglutamate and iron regulate the expression of the enzyme
-
-
?
additional information
?
-
-
pyroglutamate and iron regulate the expression of the enzyme
-
-
?
additional information
?
-
-
PGAP performs enzymatic deblocking of pyroglutamylated immunoglobulins. Unfolding of immunoglobulins is required for excision of the pyroglutamate. The enzyme requires the substrate in an extended conformation, which is not fullfiled in the native form of immunoglobulins
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina
-
-
?
additional information
?
-
-
pyroglutamyl peptidase I levels and their left-right distribution in the rat retina and hypothalamus are influenced by light-dark conditions
-
-
?
additional information
?
-
the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
additional information
?
-
-
the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides
-
-
?
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Substrate specificity of pyroglutamylaminopeptidase
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Some properties of synaptosomal membrane-bound pyroglutamate aminopeptidase from guinea-pig brain
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-
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Bacillus amyloliquefaciens
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Cavia porcellus
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An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro
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5
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Bacillus amyloliquefaciens
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Bacillus amyloliquefaciens
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702
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1980
Bacillus amyloliquefaciens
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The substrate specificity of pyrrolidone carboxylyl peptidase from Bacillus amyloliquefaciens
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1979
Bacillus amyloliquefaciens
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Reversible inhibition of the membrane-bound pyrrolidonecarboxylpeptidase in Streptococcus cremoris, caused by organic solvents
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Lactococcus cremoris
-
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Pimelobacter simplex, Bacillus amyloliquefaciens, Niallia circulans, Priestia megaterium, Bacillus subtilis, Paenibacillus polymyxa, Micrococcus luteus, Proteus vulgaris, Pseudomonas aeruginosa
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Bacillus amyloliquefaciens
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Pyrrolidonecarboxylyl peptidase: stabilization and purification
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28
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Bos taurus
brenda
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The unusually slow unfolding rate causes the high stability of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyroccoccus furiosus: equilibrium and kinetic studies of guanidine hydrochloride-induced unfolding and refolding
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37
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1998
Bacillus amyloliquefaciens, Pyrococcus furiosus
brenda
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Pyroglutamate aminopeptidase in rat submaxillary gland
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29
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1992
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A study of a highly specific pyroglutamyl aminopeptidase type-II from the membrane fraction of bovine brain
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30
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1998
Bacillus amyloliquefaciens, Bacillus subtilis, Bos taurus
brenda
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Pyrrolidone carboxyl peptidase (Pcp): An enzyme that removes pyroglutamic acid (pGlu) from pGlu peptides and pGlu-proteins
Proteins Struct. Funct. Genet.
20
34-51
1994
Enterobacter cloacae, Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Enterococcus faecium, Homo sapiens, Pseudomonas fluorescens, Rattus norvegicus, Streptococcus pyogenes, Sus scrofa
brenda
Mantle, D.; Lauffart, B.; Gibson, A.
Purification and characterization of leucyl aminopeptidase and pyroglutamyl aminopeptidase from human skeletal muscle
Clin. Chim. Acta
197
35-46
1991
Homo sapiens
brenda
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Thyrotropin-releasing hormone-degrading enzyme in human serum is classified as type II of pyroglutamyl aminopeptidase: influence of thyroid status
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346-351
1990
Homo sapiens
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Bacillus subtilis
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55
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Thermococcus litoralis
brenda
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Pyroglutamic acid and iron regulate the expression of the pcp gene in Pseudomonas fluorescens MFO
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Pseudomonas fluorescens, Pseudomonas fluorescens MFO
brenda
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Rattus norvegicus
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1992
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brenda
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Bacillus subtilis
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Rattus norvegicus
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Rattus norvegicus
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Rattus norvegicus
brenda
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Rattus norvegicus
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Mus musculus, Rattus norvegicus
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Rattus norvegicus
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15
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Thermococcus litoralis
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Enhancement of the thermal stability of pyroglutamyl peptidase I by introduction of an intersubunit disulfide bond
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Bacillus amyloliquefaciens
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Pyrococcus furiosus
brenda
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Bos taurus
brenda
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Pyrococcus furiosus
brenda
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Bacillus amyloliquefaciens
brenda
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Pyrococcus furiosus
brenda
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Pyrrolidone carboxylpeptidase from Thermococcus litoralis
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330
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Thermococcus litoralis
brenda
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Subcellular ontogeny of brain pyroglutamyl peptidase I
Peptides
21
509-517
2000
Rattus norvegicus
brenda
Dando, P.M.; Fortunato, M.; Strand, G.B.; Smith, T.S.; Barrett, A.J.
Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme
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28
111-119
2003
Homo sapiens (Q9NXJ5), Homo sapiens
brenda
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Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain
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383
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2005
Homo sapiens, Rattus norvegicus
brenda
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Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts
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394
635-645
2006
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Completely buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles
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45
7100-7112
2006
Pyrococcus furiosus (O73944), Pyrococcus furiosus
brenda
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Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid
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2004
Homo sapiens, Mus musculus, Rattus norvegicus
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Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain
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2004
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brenda
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Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease
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18
637-644
2006
Homo sapiens (Q9NXJ5)
brenda
Garcia-Lopez, M.J.; Martinez-Martos, J.M.; Mayas, M.D.; Carrera, M.P.; Ramirez-Exposito, M.J.
Effects of orchidectomy and testosterone replacement on mouse pyrrolidone carboxypeptidase activity in the HPA axis
Horm. Metab. Res.
36
131-135
2004
Mus musculus (Q9ESW8), Mus musculus
brenda
Carrera, M.P.; Ramirez-Exposito, M.J.; Valenzuela, M.T.; Garcia, M.J.; Mayas, M.D.; De Saavedra, J.M.; Sanchez, R.; Perez, M.C.; Martinez-Martos, J.M.
Pyrrolidon (sic) carboxypeptidase activities in the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-ovary axes of rats with mammary gland cancer induced by N-methyl nitrosourea
Horm. Metab. Res.
37
74-78
2005
Rattus norvegicus
brenda
Valdivia, A.; Irazusta, J.; Fernandez, D.; Mugica, J.; Ochoa, C.; Casis, L.
Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia
Regul. Pept.
122
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2004
Homo sapiens
brenda
Iimura, S.; Umezaki, T.; Takeuchi, M.; Mizuguchi, M.; Yagi, H.; Ogasahara, K.; Akutsu, H.; Noda, Y.; Segawa, S.; Yutani, K.
Characterization of the denatured structure of pyrrolidone carboxyl peptidase from a hyperthermophile under nondenaturing conditions: role of the C-terminal alpha-helix of the protein in folding and stability
Biochemistry
46
3664-3672
2007
Pyrococcus furiosus (O73944), Pyrococcus furiosus
brenda
Hellstroem, J.L.; Vehniaeinen, M.; Mustonen, M.; Loevgren, T.; Lamminmaeki, U.; Hellman, J.
Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues
Biochim. Biophys. Acta
1764
1735-1740
2006
Pyrococcus furiosus
brenda
Marinho, C.E.; Olivo, R.d.o.A.; Zambotti-Villela, L.; Ribeiro-de-Andrade, T.N.; Fernandes, C.M.; Silveira, P.F.
Renal and macrophage aminopeptidase activities in cyclosporin-treated mice
Int. Immunopharmacol.
6
415-425
2006
Mus musculus
brenda
Schaeffer, M.; de Miranda, A.; Mottram, J.C.; Coombs, G.H.
Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I
Mol. Biochem. Parasitol.
150
318-329
2006
Leishmania major
brenda
Kilbane, Z.; Vaas, P.R.; Cuiv, P.O.; OConnor, B.
Cloning and heterologous expression of bovine pyroglutamyl peptidase type-1 in Escherichia coli: purification, biochemical and kinetic characterisation
Mol. Cell. Biochem.
297
189-197
2007
Bos taurus
brenda
Zambotti-Villela, L.; Yamasaki, S.C.; Villarroel, J.S.; Murena-Nunes, C.; Silveira, P.F.
Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats
Peptides
28
1586-1595
2007
Rattus norvegicus
brenda
Agirregoitia, N.; Casis, L.; Gil, J.; Ruiz, F.; Irazusta, J.
Ontogeny of prolyl endopeptidase and pyroglutamyl peptidase I in rat tissues
Regul. Pept.
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52-58
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Rattus norvegicus
brenda
Marinho, C.; SM, A.; Yamasaki, S.; Silveira, P.
Seasonal variation of peptidase activities in the reproductive tract of Crotalus durissus terrificus
Gen. Comp. Endocrinol.
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2009
Crotalus durissus terrificus
brenda
Tsunasawa, S.; Nakura, S.; Tanigawa, T.; Kato, I.
Pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Pyrococcus furiosus: cloning and overexpression in Escherichia coli of the gene, and its application to protein sequence analysis
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1998
Pyrococcus furiosus (O73944), Pyrococcus furiosus
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Sokabe, M.; Kawamura, T.; Sakai, N.; Yao, M.; Watanabe, N.; Tanaka, I.
The X-ray crystal structure of pyrrolidone-carboxylate peptidase from hyperthermophilic archaea Pyrococcus horikoshii
J. Struct. Funct. Genomics
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145-154
2002
Pyrococcus horikoshii (O58321), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O58321)
brenda
Sokol, B.; Hofstad, T.
Enzyme profiles of Clostridium difficile strains isolated from children
Cytobios
66
35-40
1991
Clostridioides difficile
brenda
Singleton, M.R.; Taylor, S.J.; Parrat, J.S.; Littlechild, J.A.
Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis
Extremophiles
4
297-303
2000
Thermococcus litoralis (O07883), Thermococcus litoralis, Thermococcus litoralis DSM 5473 (O07883)
brenda
Mizuguchi, M.; Takeuchi, M.; Ohki, S.; Nabeshima, Y.; Kouno, T.; Aizawa, T.; Demura, M.; Kawano, K.; Yutani, K.
Structural characterization of a trapped folding intermediate of pyrrolidone carboxyl peptidase from a hyperthermophile
Biochemistry
51
6089-6096
2012
Pyrococcus furiosus (O73944)
brenda
Carrera-Gonzalez, M. del P.; Ramirez-Exposito, M.J.; Duenas, B.; Martinez-Ferrol, J.; Mayas, M.D.; Martinez-Martos, J.M.
Putative relationship between hormonal status and serum pyrrolidone carboxypeptidase activity in pre- and post-menopausal women with breast cancer
Breast
21
751-754
2012
Homo sapiens
brenda
Megias, M.J.; Alba-Araguez, F.; Luna, J.D.; Vives, F.; Ramirez-Sanchez, M.
Serum pyroglutamyl aminopeptidase activity: apromising novel biomarker candidate for liver cirrhosis
Endocr. Regul.
49
20-24
2015
Homo sapiens
brenda
Compton, S.; Kania, S.; Robertson, A.; Lawhon, S.; Jenkins, S.; Westblade, L.; Bemis, D.
Evaluation of pyrrolidonyl arylamidase activity in Staphylococcus delphini
J. Clin. Microbiol.
55
859-864
2017
Enterococcus faecalis, no activity in Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus delphini, no activity in Staphylococcus pseudintermedius, Staphylococcus delphini MI 09-8445, no activity in Staphylococcus aureus ATCC 25923, Staphylococcus pseudintermedius LMG 22219T, Staphylococcus delphini 56-039, Staphylococcus delphini 53-033, Staphylococcus delphini VPP 12 D, Enterococcus faecalis ATCC 29212, Staphylococcus delphini 52-006, Staphylococcus delphini 56-021, Staphylococcus delphini 62-031, Staphylococcus delphini MI 16-1129, no activity in Staphylococcus pseudintermedius LMG 22219T, Staphylococcus delphini MI 09-2894, Staphylococcus delphini 49-046
brenda