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Literature summary for 3.4.19.3 extracted from

  • Mantle, D.; Lauffart, B.; Gibson, A.
    Purification and characterization of leucyl aminopeptidase and pyroglutamyl aminopeptidase from human skeletal muscle (1991), Clin. Chim. Acta, 197, 35-46.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol absolute requirement for maintenance of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
amastatin
-
Homo sapiens
Arphamenine B
-
Homo sapiens
chymostatin
-
Homo sapiens
Elastinal
-
Homo sapiens
leupeptin
-
Homo sapiens
NEM
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
pyroglutamate-4-methylcoumarin 7-amide
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information maximal activity in absence of divalent cations Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle quadriceps muscle Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.093
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
luliberin + H2O
-
Homo sapiens pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
?
neurotensin + H2O
-
Homo sapiens pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
-
Homo sapiens pyroglutamate + 7-amino-4-methylcoumarin
-
?
thyroliberin + H2O
-
Homo sapiens pyroglutamate + His-Pro-NH2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 50% of maximal activity at pH 7 and at pH 9.5 Homo sapiens