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Literature summary for 3.4.19.3 extracted from

  • Abe, K.; Saito, F.; Yamada, M.; Tokui, T.
    Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid (2004), Biol. Pharm. Bull., 27, 113-116.
    View publication on PubMed
Search for more literature for 3.4.19.3

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Homo sapiens
0.046
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Mus musculus
0.057
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
0.14
-
 L-pyroglutamyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
0.3
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
0.33
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
0.33
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
0.37
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
0.42
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
0.43
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
0.5
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Homo sapiens
0.55
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Rattus norvegicus
0.55
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
0.57
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
0.57
-
 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
0.58
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Mus musculus
0.62
-
 L-2-oxothiazolidine-4-carboxyl-ethanolamine 37°C, pH 7.4 Rattus norvegicus
0.71
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
1.43
-
 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
1.53
-
 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Mus musculus L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Homo sapiens L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
-
 Rattus norvegicus L-2-oxothiazolidine-4-carboxylic acid + ?
-
 ?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-ethanolamine + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Mus musculus ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Homo sapiens ?
-
 ?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
-
 Rattus norvegicus ?
-
 ?
L-pyroglutamyl-aminoethylnitrate + H2O
-
 Rattus norvegicus ?
-
 ?
L-pyroglutamyl-L-Ala + H2O
-
 Mus musculus L-pyroglutamate + L-Ala
-
 ?
L-pyroglutamyl-L-Ala + H2O
-
 Homo sapiens L-pyroglutamate + L-Ala
-
 ?
L-pyroglutamyl-L-Ala + H2O
-
 Rattus norvegicus L-pyroglutamate + L-Ala
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.9
-
 L-2-oxothiazolidine-4-carboxyl-ethanolamine 37°C, pH 7.4 Rattus norvegicus
1.5
-
 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
1.8
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Homo sapiens
2.3
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Mus musculus
2.3
-
 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide 37°C, pH 7.4 Rattus norvegicus
2.3
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
2.4
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Homo sapiens
2.4
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
2.5
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
2.7
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
3.2
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Mus musculus
3.2
-
 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate 37°C, pH 7.4 Rattus norvegicus
3.4
-
 L-2-oxothiazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.5
-
 L-pyroglutamyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
3.6
-
 L-2-oxoimidazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
3.7
-
 L-pyroglutamyl-L-Ala 37°C, pH 7.4 Rattus norvegicus
6.4
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Homo sapiens
6.6
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Mus musculus
7.6
-
 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate 37°C, pH 7.4 Rattus norvegicus
8.1
-
 L-2-oxooxazolidine-4-carboxyl-L-Ala 37°C, pH 7.4 Rattus norvegicus