Literature summary for 3.4.19.3 extracted from

Alur, H.H.; Desai, R.P.; Mitra, A.K.; Johnston, T.P.
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa (2001), Int. J. Pharm., 212, 171-176.

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Application

Application	Comment	Organism
medicine	the natural oligosaccharide gum from Hakea gibbosa is an effective non-competitive inhibitor. The natural gum may be a promising additive not only for its sustained-release and mucoadhesive properties, but also for its ability to slow the enzymatic degradation of therapeutic polypeptides incorporated in dosage forms	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
natural oligosaccharide gum from Hakea gibbosa	effective non-competitive inhibitor. The natural gum may be a promising additive not only for its sustained-release and mucoadhesive properties, but also for its ability to slow the enzymatic degradation of therapeutic polypeptides incorporated in dosage forms	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-pyroglutamyl-beta-naphthylamide + H2O	-	Bos taurus	L-pyroglutamate + beta-naphthylamine	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	Ki for the natural oligosaccharide gum from Hakea gibbosa is 0.31% w/v	Bos taurus

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Release 2023.1 (January 2023)