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Literature summary for 3.4.19.3 extracted from
- Pyrrolidone carboxyl peptidase (Pcp): An enzyme that removes pyroglutamic acid (pGlu) from pGlu peptides and pGlu-proteins (1994), Proteins Struct. Funct. Genet., 20, 34-51.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Cavia porcellus |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Homo sapiens |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Rattus norvegicus |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Sus scrofa |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Bos taurus |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Oryctolagus cuniculus |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Enterobacter cloacae |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Streptococcus pyogenes |
| analysis | application to N-terminal pyroglutamyl unblocking prior to Edman sequential degradation in peptide and protein sequencing | Enterococcus faecium |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
skeletal muscle and kidney enzyme | Homo sapiens |
| 23000 | - |
enzyme from cerebral cortex | Homo sapiens |
| 24000 | - |
- |
Cavia porcellus |
| 25000 | - |
- |
Bos taurus |
| 41000 | - |
- |
Pseudomonas fluorescens |
| 55000 | 65000 | enzyme from brain | Rattus norvegicus |
| 74000 | - |
- |
Enterobacter cloacae |
| 85000 | - |
- |
Streptococcus pyogenes |
| 230000 | - |
- |
Cavia porcellus |
| 230000 | - |
- |
Oryctolagus cuniculus |
| 240000 | - |
enzyme from liver | Rattus norvegicus |
| 260000 | - |
- |
Sus scrofa |
| 260000 | - |
enzyme from serum | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Pseudomonas fluorescens | - |
? | - |
? |  |
| additional information | Cavia porcellus | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Homo sapiens | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Sus scrofa | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Bos taurus | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Oryctolagus cuniculus | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Enterobacter cloacae | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Streptococcus pyogenes | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
| additional information | Enterococcus faecium | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Enterobacter cloacae | - |
- |
- |
| Enterococcus faecium | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Pseudomonas fluorescens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Streptococcus pyogenes | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| brain | - |
Oryctolagus cuniculus | - |
| brain | cerebral cortex | Homo sapiens | - |
| hypophysis | - |
Bos taurus | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| serum | - |
Homo sapiens | - |
| serum | - |
Rattus norvegicus | - |
| serum | - |
Sus scrofa | - |
| skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
Pseudomonas fluorescens | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Cavia porcellus | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Homo sapiens | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Sus scrofa | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Bos taurus | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Oryctolagus cuniculus | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Enterobacter cloacae | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Streptococcus pyogenes | ? | - |
? | |
| additional information | the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides | Enterococcus faecium | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 8 | - |
Rattus norvegicus |
| 6.5 | 8 | - |
Sus scrofa |
| 6.5 | 8.5 | - |
Pseudomonas fluorescens |
| 7 | - |
- |
Streptococcus pyogenes |
| 7.3 | - |
pituitary enzyme | Bos taurus |
| 7.6 | - |
- |
Enterococcus faecium |
| 8 | - |
enzyme from kidney | Homo sapiens |
| 8.5 | - |
- |
Bos taurus |
| 8.5 | - |
enzyme from skeletal muscle and cerebral cortex | Homo sapiens |
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