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Literature summary for 3.4.19.3 extracted from

  • Taylor, W.L.; Dixon, J.E.
    Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone (1978), J. Biol. Chem., 253, 6934-6940.
    View publication on PubMed
Search for more literature for 3.4.19.3

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Rattus norvegicus
Cu2+ CuCl2 Rattus norvegicus
EDTA
-
 Rattus norvegicus
EGTA
-
 Rattus norvegicus
Hg2+ HgCl2 Rattus norvegicus
Luteinizing hormone-releasing hormone inhibits hydrolysis of thyrotropin-releasing hormone Rattus norvegicus
pyroglutamyl-His methyl ester inhibits hydrolysis of thyrotropin-releasing hormone Rattus norvegicus
pyroglutamyl-L-dopa-Pro-NH2 inhibits hydrolysis of thyrotropin-releasing hormone Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
 thyrotrophic hormone releasing hormone
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
260000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thyroliberin + H2O
-
 Rattus norvegicus pyroglutamate + His-Pro-NH2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8 hydrolysis of thyrotrophic hormone releasing hormone Rattus norvegicus