Reference on EC 3.1.4.35 - 3',5'-cyclic-GMP phosphodiesterase and Organism(s) Rattus norvegicus and UniProt Accession Q8QZV1
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Francis, S.H.; Corbin, J.D.
Purification of cGMP-binding protein phosphodiesterase from rat lung
Methods Enzymol.
159
722-729
1988
Rattus norvegicus
Russell, T.R.; Terasaki, W.L.; Appleman, M.M.
Separate phosphodiesterases for the hydrolysis of cyclic adenosine 3,5-monophosphate and cyclic guanosine 3,5-monophosphate in rat liver
J. Biol. Chem.
248
1334-1340
1973
Rattus norvegicus
Tanaka, S.; Shimooka, S.; Shimomura, H.
Changes in phosphodiesterase activity in the developing rat submandibular gland
Arch. Oral Biol.
47
567-576
2002
Rattus norvegicus
Okada, D.; Asakawa, S.
Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMP
Biochemistry
41
9672-9679
2002
Rattus norvegicus
Hosogai, N.; Seki, J.; Goto, T.
Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity
Br. J. Pharmacol.
134
995-1002
2001
Rattus norvegicus
van Staveren, W.C.; Glick, J.; Markerink-van Ittersum, M.; Shimizu, M.; Beavo, J.A.; Steinbusch, H.W.; de Vente, J.
Cloning and localization of the cGMP-specific phosphodiesterase type 9 in the rat brain
J. Neurocytol.
31
729-741
2002
Mus musculus (O70628), Mus musculus, Rattus norvegicus (Q8QZV1)
Ni, X.P.; Safai, M.; Gardner, D.G.; Humphreys, M.H.
Increased cGMP phosphodiesterase activity mediates renal resistance to ANP in rats with bile duct ligation
Kidney Int.
59
1264-1273
2001
Rattus norvegicus
Buhimschi, C.S.; Garfield, R.E.; Weiner, C.P.; Buhimschi, I.A.
The presence and function of phosphodiesterase type 5 in the rat myometrium
Am. J. Obstet. Gynecol.
190
268-274
2004
Rattus norvegicus
Castro, L.R.; Verde, I.; Cooper, D.M.; Fischmeister, R.
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes
Circulation
113
2221-2228
2006
Rattus norvegicus
Scipioni, A.; Stefanini, S.; Santone, R.; Giorgi, M.
Immunohistochemical localisation of PDE5 in Leydig and myoid cells of prepuberal and adult rat testis
Histochem. Cell Biol.
124
401-407
2005
Rattus norvegicus
Mo, E.; Amin, H.; Bianco, I.H.; Garthwaite, J.
Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway
J. Biol. Chem.
279
26149-26158
2004
Rattus norvegicus
Keravis, T.; Thaseldar-Roumie, R.; Lugnier, C.
Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts
Methods Mol. Biol.
307
63-74
2005
Rattus norvegicus
Knight, S.; Snellen, H.; Humphreys, M.; Baylis, C.
Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat
Am. J. Physiol. Renal Physiol.
292
F655-F659
2007
Rattus norvegicus
Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Biochim. Biophys. Acta
1773
209-218
2007
Rattus norvegicus
Nagendran, J.; Archer, S.L.; Soliman, D.; Gurtu, V.; Moudgil, R.; Haromy, A.; St Aubin, C.; Webster, L.; Rebeyka, I.M.; Ross, D.B.; Light, P.E.; Dyck, J.R.; Michelakis, E.D.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
Circulation
116
238-248
2007
Homo sapiens, Rattus norvegicus
Filippi, S.; Morelli, A.; Sandner, P.; Fibbi, B.; Mancina, R.; Marini, M.; Gacci, M.; Vignozzi, L.; Vannelli, G.B.; Carini, M.; Forti, G.; Maggi, M.
Characterization and functional role of androgen-dependent PDE5 activity in the bladder
Endocrinology
148
1019-1029
2007
Homo sapiens, Rattus norvegicus
Rutten, K.; Prickaerts, J.; Hendrix, M.; van der Staay, F.J.; Sik, A.; Blokland, A.
Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
Eur. J. Pharmacol.
558
107-112
2007
Rattus norvegicus
de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
J. Chem. Neuroanat.
31
275-303
2006
Rattus norvegicus (O54735)
Domek-Lopacinska, K.; Strosznajder, J.B.
The effect of selective inhibition of cyclic GMP hydrolyzing phosphodiesterases 2 and 5 on learning and memory processes and nitric oxide synthase activity in brain during aging
Brain Res.
1216
68-77
2008
Rattus norvegicus
Chen, J.; Yoshida, T.; Bitensky, M.W.
Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina
Mol. Vis.
14
2509-2517
2008
Rattus norvegicus
Matsumoto, S.; Hanai, T.; Uemura, H.; Levin, R.M.
Effects of chronic treatment with vardenafil, a phosphodiesterase 5 inhibitor, on female rat bladder in a partial bladder outlet obstruction model
BJU Int.
103
987-990
2009
Rattus norvegicus
Radovits, T.; Boemicke, T.; Koekeny, G.; Arif, R.; Loganathan, S.; Kecsan, K.; Korkmaz, S.; Barnucz, E.; Sandner, P.; Karck, M.; Szabo, G.
The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus
Br. J. Pharmacol.
156
909-919
2009
Rattus norvegicus
Schaefer, S.; Ellinghaus, P.; Janssen, W.; Kramer, F.; Lustig, K.; Milting, H.; Kast, R.; Klein, M.
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling
Cardiovasc. Res.
82
30-39
2009
Rattus norvegicus
Dadvar, P.; Kovanich, D.; Folkers, G.E.; Rumpel, K.; Raijmakers, R.; Heck, A.J.
Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors
ChemBioChem
10
2654-2662
2009
Rattus norvegicus (O54735)
Toque, H.A.; Priviero, F.B.; Zemse, S.M.; Antunes, E.; Teixeira, C.E.; Webb, R.C.
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects
Clin. Exp. Pharmacol. Physiol.
36
358-366
2009
Rattus norvegicus
Sun, X.Z.; Li, Z.F.; Liu, Y.; Fang, P.; Li, M.X.
Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells
Clin. Exp. Pharmacol. Physiol.
37
362-367
2010
Rattus norvegicus
Gotshall, R.W.; Hamilton, K.L.; Foreman, B.; van Patot, M.C.; Irwin, D.C.
Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition
Crit. Care Med.
37
1988-1993
2009
Rattus norvegicus
Kato, N.; Mashita, Y.; Kato, S.; Mitsufuji, S.; Yoshikawa, T.; Takeuchi, K.
Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism
Digest. Dis. Sci.
54
2346-2356
2009
Rattus norvegicus
Liu, C.Q.; Leung, F.P.; Lee, V.W.; Lau, C.W.; Yao, X.; Lu, L.; Huang, Y.
Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor
Eur. J. Pharmacol.
590
250-254
2008
Rattus norvegicus
Korkmaz, S.; Radovits, T.; Barnucz, E.; Neugebauer, P.; Arif, R.; Hirschberg, K.; Loganathan, S.; Seidel, B.; Karck, M.; Szabo, G.
Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta
Eur. J. Pharmacol.
615
155-162
2009
Rattus norvegicus
Iseri, S.O.; Ersoy, Y.; Ercan, F.; Yuksel, M.; Atukeren, P.; Gumustas, K.; Alican, I.
The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat
J. Gastroenterol. Hepatol.
24
1142-1148
2009
Rattus norvegicus
Hughes, R.O.; Rogier, D.J.; Jacobsen, E.J.; Walker, J.K.; Macinnes, A.; Bond, B.R.; Zhang, L.L.; Yu, Y.; Zheng, Y.; Rumsey, J.M.; Walgren, J.L.; Curtiss, S.W.; Fobian, Y.M.; Heasley, S.E.; Cubbage, J.W.; Moon, J.B.; Brown, D.L.; Acker, B.A.; Maddux, T.M.; Tollefson, M.B.; Mischke, B.V.; Owen, D.R.; Freskos, J.N.; Molyneaux, J.M.; Benson, A.G.; Blevis-Bal, R.M.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5)
J. Med. Chem.
53
2656-2660
2010
Rattus norvegicus
Pifarre, P.; Prado, J.; Giralt, M.; Molinero, A.; Hidalgo, J.; Garcia, A.
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury
J. Neurochem.
112
807-817
2010
Rattus norvegicus
Li, M.; Sun, X.; Li, Z.; Liu, Y.
Inhibition of cGMP phosphodiesterase 5 suppresses serotonin signalling in pulmonary artery smooth muscles cells
Pharmacol. Res.
59
312-318
2009
Rattus norvegicus
Clark, A.S.; Meerts, S.H.; Guarraci, F.A.
Zaprinast, a phosphodiesterase type-5 inhibitor, alters paced mating behavior in female rats
Physiol. Behav.
96
289-293
2009
Rattus norvegicus
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Kelly, M.P.; Adamowicz, W.; Bove, S.; Hartman, A.J.; Mariga, A.; Pathak, G.; Reinhart, V.; Romegialli, A.; Kleiman, R.J.
Select 3,5-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
Cell. Signal.
26
383-397
2014
Mus musculus, Rattus norvegicus
